chlorine(.)

Two steps

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• cholesterol sulfateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Steryl-Sulfatase

  Catalysed by SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 2 routes

• 5alpha-dihydrotestosterone sulfateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SLC26A6, STSextracellular space, cytosolOne of 3 routes

• acetoacetateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of acetoacetate and formate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

• an aryl sulfateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SLC26A6, ARSL, ARSF, ARSK and 3 moreextracellular space, cytosol

• N-hexadecanoylglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL3extracellular space, cytosol

• N-dodecanoylglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-decanoylglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-octanoylglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• L-homoarginineReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by SLC6A14, SLC25A29extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homocarnosineReach from here →
  1. transport of chloride and histidine (cytosol to extracellular)
  2. Formation of homocarnosine

  Catalysed by SLC6A14, CARNS1extracellular space, cytosolOne of 3 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC6A9, SLC6A14, GARTextracellular space, cytosol

• L-cystine-bis-glycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC6A9, SLC6A14, DPEP1, DPEP2extracellular space, cytosol

• glycyldehydrophenylalanineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC6A9, SLC6A14, DPEP1extracellular space, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC6A14, PFASextracellular space, cytosol

• kinetensinReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. Chymase

  Catalysed by SLC6A14, CMA1extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• acetaldehydeReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC6A14extracellular space, cytosol

• acetylcholineReach from here →
  1. transport of chloride and choline (cytosol to extracellular)
  2. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by SLC5A7, CHATextracellular space, cytosolOne of 3 routes

• pyruvateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A7 and 2 moreextracellular space, cytosolOne of 18 routes

• all-trans-retinoic acidReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and retinoate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by SLC6A14, PAHextracellular space, cytosolOne of 3 routes

• CHEBI:15477Reach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC6A5, GLYAT, GLYATL2, GLYATL1extracellular space, cytosol, mitochondrial matrix

• propionyl-CoAReach from here →
  1. Carnitine Transport by Atb0
  2. Active Transport

  Catalysed by SLC6A14extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15570Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC3A2, SLC7A10extracellular space, cytosolOne of 5 routes

• (S)-malateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of malate and sulfate (cytosol to mitochondria)

  Catalysed by SLC26A6, SLC25A10extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:15611Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC6A9, SLC6A14, GNMTextracellular space, cytosol

• 10-formyltetrahydrofolic acidReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by SLC26A4, MTHFD1extracellular space, cytosolOne of 2 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC6A14, PAHextracellular space, cytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC7A5extracellular space, cytosolOne of 52 routes

• betaine aldehydeReach from here →
  1. transport of chloride and choline (cytosol to extracellular)
  2. choline dehydrogenase (choline)

  Catalysed by SLC5A7, CHDHextracellular space, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. transport of chloride and lysine (cytosol to extracellular)
  2. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC6A14, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. transport of chloride and histidine (cytosol to extracellular)
  2. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC6A14, CARNS1extracellular space, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• CHEBI:15765Reach from here →
  1. Transport of L-Tyrosine by Atb0 Transporter
  2. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC6A14, THextracellular space, cytosolOne of 5 routes

• malonateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC25A30, SLC25A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC6A14, GFPT2, GFPT1extracellular space, cytosol

• ureaReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. L-Arginine amidinohydrolase

  Catalysed by SLC6A14, ARG1extracellular space, cytosolOne of 3 routes

• succinic semialdehydeReach from here →
  1. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  2. 4-aminobutanoate:2-oxoglutarate aminotransferase

  Catalysed by SLC6A12, ABATextracellular space, cytosol, mitochondrial matrix

• L-cystineReach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by SLC6A14, SLC7A9, SLC3A1extracellular space, cytosolOne of 7 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC6A14, AGXT2extracellular space, cytosol, mitochondrial matrix

• (R)-carnitineReach from here →
  1. transport of betaine and chloride (cytosol to extracellular)
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by SLC6A12, SLC22A5extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-citrullineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosolOne of 39 routes

• nitric oxideReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC6A14, NOS3, NOS1, NOS2extracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC3A2, SLC7A10extracellular space, cytosolOne of 4 routes

• protein polypeptide chainReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. PROTEIN_BS

  Catalysed by SLC6A9, SLC6A14extracellular space, cytosolOne of 17 routes

• 2-phenylacetamideReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC6A14, EPXextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC6A14, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of chloride and methionine (cytosol to extracellular)
  2. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC6A14, MARS1extracellular space, cytosol