3,3',5-triiodo-L-thyronine sulfate

Three steps

• citric acidReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by STS, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 12 routes

• (indol-3-yl)acetateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• isocitric acidReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by STS, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 6 routes

• glutarateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by STS, SLC22A24, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by DIO1, D2HGDH, GOT2mitochondrial matrix

• pentanoateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• cis-aconitic acidReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by STS, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 6 routes

• N-carbamoyl-L-aspartateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by STS, SLC25A14, SLC25A30, CADcytosol, inner side of the membrane, outer side of the membrane

• di-mu-sulfido-diiron(2+)Reach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. De novo synthesis of 2Fe2S

  Catalysed by DIO1, MOCOS, NDUFAB1, FDXR and 5 moremitochondrial matrix

• a phenolReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by STS, ARSL, ARSF, ARSK and 3 morecytosol

• glyoxylateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by STS, SLC25A10, CLYBLcytosol, mitochondrial matrix

• 25-hydroxycholesterolReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by DIO1, AIFM1, PYROXD1, CH25H

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• all-trans-4-oxoretinolReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. cytochrome P450 (retinol)

  Catalysed by DIO1, RETSAT, CYP26A1cytosol

• phosphoenolpyruvic acidReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by DIO1, D2HGDH, PCK1cytosolOne of 2 routes

• 13-cis-retinolReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol binding protein (retinol)

  Catalysed by DIO1, RETSAT, RBP1, RBP2cytosolOne of 2 routes

• L-ornithineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by DIO1, MOCOS, SLC7A6extracellular space, cytosolOne of 2 routes

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by STS, SLC4A1, ALDH9A1cytosol, extracellular space

• taurineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by STS, SLC26A6, SLC6A6cytosol, extracellular spaceOne of 2 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, RETSATOne of 2 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO3One of 2 routes

• glycineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A9, SLC6A14cytosol, extracellular spaceOne of 7 routes

• (S)-malyl-CoAReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by STS, SLC25A10, SUCLG1, SUCLA2cytosol, mitochondrial matrix

• prostaglandin F2alphaReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin H2Reach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by DIO1, AIFM1, PYROXD1, PTGS1 and 1 moreOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by DIO1, AIFM1, PYROXD1, TBXAS1 and 2 more

• sarcosineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by DIO1, KDM1A, KDM1B, PIPOX

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)

  Catalysed by DIO1, MTO1, DHFR, DHFR2

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by STS, SLC25A10, ASLcytosol, mitochondrial matrixOne of 4 routes

• 3,5-diiodo-L-tyrosineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. iodide:hydrogen-peroxide oxidoreductase
  3. thyroid peroxidase (3-iodo-L-tyrosine)

  Catalysed by DIO1, TPOcytosolOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by STS, SLC25A10, ADSL, TNRC6Bcytosol, mitochondrial matrixOne of 4 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by DIO1, MOCOS, GOT2, GOT1cytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by DIO1, KDM1A, KDM1B, ADH1C and 5 morecytosol

• guanidinoacetateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by STS, SLC26A6cytosol, extracellular space

• 3',5'-cyclic GMPReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and methionine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 14 routes

• adenosine 5'-phosphoramidateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by STS, PAPSS1, PAPSS2, FHITcytosol

• L-tryptophanReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 8 routes

• glutathioneReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by STS, SLC25A14, SLC25A30, TSTD1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• beta-alanineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• L-alanineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 20 routes

• L-asparagineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 8 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by STS, SLC25A14, SLC25A30, AGAcytosol, inner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 10 routes

• 3',5'-cyclic AMPReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by DIO1, MOCOS, GCLC, GCLMcytosolOne of 2 routes

• glutathione disulfideReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 2 morecytosol, inner side of the membrane, outer side of the membrane

• L-tyrosineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by STS, SLC25A14, SLC25A30, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by STS, SLC25A14, SLC25A30, AGXT2cytosol, inner side of the membrane, outer side of the membrane

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by STS, SLC25A10, ADSLcytosol, mitochondrial matrixOne of 4 routes