Met-tRNA(Met)

Three steps

• agmatineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. mitothioredoxin phosphorylation
  3. L-arginine carboxy-lyase (agmatine-forming)

  No catalyst recordedcytosol, mitochondrial matrix

• AH2Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by MOCOScytosolOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by MTFMT, SHMT1, ALAS1, ALAS2 and 1 morecytosol, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by IL4I1cytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by AARS1cytosol

• trans-urocanateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by HALcytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by TPH1, TPH2cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by BCAT2cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. mitothioredoxin phosphorylation
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by SLC3A2, SLC7A6cytosol, extracellular space

• 3-phenylpyruvateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by GOT2, TATcytosol, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. sulfotransferase (thioredoxin)
  3. transport of fumarate and sulfite (cytosol to mitochondria)

  Catalysed by SULT1A3, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

• triphosphateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. dCTP + H2O = 2'-deoxycytidine + triphosphate + H(+)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 morecytosol

• dTDPReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyadenosine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. deoxythymidylate kinase (dADP)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 morecytosol, mitochondrial matrixOne of 5 routes

• dTTPReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyadenosine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 7 morecytosolOne of 3 routes

• CHEBI:18095Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. Transport of Hydroxy-Proline

  Catalysed by SLC1A4cytosol, extracellular spaceOne of 4 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by MTFMT, MTHFD1, GARTcytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by MTFMT, SHMT1, GARTcytosol

• CHEBI:18381Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by MTFMT, MTHFD1, ATICcytosolOne of 2 routes

• 2-phenylethylamineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by DDCcytosol

• hydrogen cyanideReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. sulfotransferase (thioredoxin)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SULT1A3, MPST, TSTcytosol, mitochondrial matrixOne of 2 routes

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by PFAScytosol

• (6S)-5-methyl-5,6,7,8-tetrahydrofolateReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in)

  Catalysed by MTFMT, ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

• ophthalmateReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by MTFMT, SHMT1, GSScytosol

• S-methylmercury-L-cysteineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)

  Catalysed by SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by MTFMT, SHMT1, AGXT2cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by CARS2cytosol

• CHEBI:240943Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by MTFMT, SHMT1, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrix

• dUMPReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyguanosine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. thymidine kinase (deoxyuridine)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosolOne of 6 routes

• potassium atomReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. transport of aspartate (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 1 morecytosol, extracellular space

• folic acidReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by MTFMT, DHFR, DHFR2cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by MTFMT, SHMT1, GLYATcytosolOne of 3 routes

• selenomethionineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. histamine N-methyltransferase (SAM)
  3. Methionine Synthase

  Catalysed by MTFMT, HNMTcytosol, nucleusOne of 2 routes

• 5-hydroxytryptophanReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by TPH1, TPH2cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. LTD4 hydrolysis

  Catalysed by MTFMT, SHMT1cytosol

• pyridoxine 5'-phosphateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SCLYcytosol

• N-acetyl-L-cysteineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by NAGScytosol, mitochondrial matrix

• K(+)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Cys-tRNA(Cys)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by CARS1cytosol

• Phe-tRNA(Phe)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by FARSB, FARSAcytosol

• Gly-tRNA(Gly)Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by MTFMT, SHMT1, GARS1cytosol

• Asp-tRNA(Asp)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by DARS1cytosol

• Trp-tRNA(Trp)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by WARS1cytosol

• Ile-tRNA(Ile)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by IARS1cytosol

• Gln-tRNA(Gln)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by QARS1cytosol

• Asn-tRNA(Asn)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by NARS1cytosol

• chlorine(.)Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by MTFMT, SHMT1, SLC6A9, SLC6A14cytosol, extracellular spaceOne of 31 routes

• glycocholateReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by MTFMT, SHMT1, BAATcytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by CTHcytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by IDO1, TDO2, IDO2cytosol