Met-tRNA(Met)

Three steps

• N-octanoylglycineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by MTFMT, SHMT1, GLYATL2cytosol

• L-homoarginineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. mitothioredoxin phosphorylation
  3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by SLC25A29cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homocarnosineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. Formation of homocarnosine

  Catalysed by CARNS1cytosol

• 2',3'-cGAMPReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

  Catalysed by MTFMT, ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by MTFMT, SHMT1, GARTcytosol

• L-cystine-bis-glycineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by MTFMT, SHMT1, DPEP1, DPEP2cytosol

• glycyldehydrophenylalanineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by MTFMT, SHMT1, DPEP1cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by PFAScytosol

• kinetensinReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. Chymase

  Catalysed by CMA1cytosol, extracellular spaceOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by MTFMT, SHMT1, GLYATL2cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by MTFMT, SHMT1, GLYATL2cytosol

• acetaldehydeReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  No catalyst recordedcytosol

• pyruvateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
  3. dATP:pyruvate 2-O-phosphotransferase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 3 morecytosolOne of 20 routes

• 5,6,7,8-tetrahydrobiopterinReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. histamine N-methyltransferase (SAM)
  3. 5-methyl-THF to 5,10-methylene-THF conversion

  Catalysed by MTFMT, HNMTcytosol

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by PAHcytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by MTFMT, SHMT1, SLC3A2, SLC7A10cytosol, extracellular spaceOne of 5 routes

• (S)-malateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. sulfotransferase (thioredoxin)
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by SULT1A3, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15611Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by MTFMT, SHMT1, GNMTcytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by PAHcytosolOne of 2 routes

• 2'-deoxycytidineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. dCTP + H2O = 2'-deoxycytidine + triphosphate + H(+)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 morecytosol

• CHEBI:15699Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by MTFMT, SHMT1, SLC7A5cytosol, extracellular spaceOne of 52 routes

• trimethylenediamineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by DHPScytosol

• CHEBI:15727Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by CARNS1cytosol

• CHEBI:15765Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. solute carrier (L-dopa)

  Catalysed by SLC3A2, SLC7A5cytosol, extracellular spaceOne of 5 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by CADcytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyadenosine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. dATP:D-glucosamine 6-phosphotransferase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 4 morecytosolOne of 2 routes

• keto-D-fructose 6-phosphateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyadenosine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. dATP:D-fructose 6-phosphotransferase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 5 morecytosol

• sulfateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. sulfotransferase (thioredoxin)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SULT1A3, SUOXcytosol, mitochondrial matrixOne of 7 routes

• ureaReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. mitothioredoxin phosphorylation
  3. L-Arginine amidinohydrolase

  Catalysed by ARG1cytosolOne of 3 routes

• L-cystineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by SLC7A9, SLC3A1cytosol, extracellular spaceOne of 9 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AGXT2cytosol, mitochondrial matrix

• L-citrullineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by MTFMT, SHMT1, SLC7A9, SLC3A1 and 1 morecytosol, extracellular spaceOne of 39 routes

• iodideReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. thyroid peroxidase (iodine)

  Catalysed by TPOcytosolOne of 2 routes

• oxaloacetateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Aspartate:2-oxoglutarate aminotransferase

  Catalysed by GOT2cytosol, mitochondrial matrixOne of 5 routes

• nitric oxideReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. mitothioredoxin phosphorylation
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by NOS3, NOS1, NOS2cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by MTFMT, SHMT1, SLC3A2, SLC7A10cytosol, extracellular spaceOne of 4 routes

• protein polypeptide chainReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. PROTEIN_BS

  Catalysed by MTFMT, SHMT1cytosolOne of 18 routes

• 2-phenylacetamideReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by EPXcytosol

• CHEBI:16633Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SCLYcytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by AADATcytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by CNDP2cytosol

• 2-oxobutanoateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SDS, SDSLcytosol

• tryptamineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-tryptophan decarboxy-lyase

  Catalysed by DDCcytosol

• 2-oxoglutaramateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by KYAT1cytosolOne of 3 routes

• CHEBI:16856Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by MTFMT, SHMT1, GSScytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by MTFMT, SHMT1, DAOcytosol, peroxisome

• ferrocytochrome cReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. sulfotransferase (thioredoxin)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SULT1A3, SUOXcytosol, mitochondrial matrix

• N-acetyl-L-aspartateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by NAT8Lcytosol, mitochondrial matrixOne of 2 routes

• CHEBI:17380Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by PRODH2cytosolOne of 2 routes