CHEBI:16523

Three steps

• CHEBI:15650Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by SLC3A2, SLC7A10, ZDHHC11B, NAA10 and 30 moreextracellular space, cytosolOne of 6 routes

• trimethylenediamineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC3A2, SLC7A10, SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and histidine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC3A2, SLC7A10, SLC7A6, CARNS1extracellular space, cytosolOne of 2 routes

• CHEBI:15746Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SLC3A2, SLC7A10, SAT1, SAT2extracellular space, cytosolOne of 2 routes

• CHEBI:15765Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC3A2, SLC7A10, SLC7A5, THextracellular space, cytosolOne of 5 routes

• bromideReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by SLC3A2, SLC7A10, GSS, MGST3 and 16 moreextracellular space, cytosolOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SLC3A2, SLC7A10, CADextracellular space, cytosolOne of 2 routes

• keto-D-fructose 6-phosphateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)

  Catalysed by SLC3A2, SLC7A10, GFPT2, GFPT1 and 2 moreextracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. L-Glutamine:tRNA(Gln) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by SLC3A2, SLC7A10, QARS1extracellular space, cytosolOne of 4 routes

• a halide anionReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SLC3A2, SLC7A10, GSS, GSTT4 and 22 moreextracellular space, cytosol

• sulfateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10, SLC6A14, SLC26A6extracellular space, cytosolOne of 3 routes

• ureaReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by SLC3A2, SLC7A10, SLC7A6, ARG1extracellular space, cytosolOne of 3 routes

• L-cystineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. L-Glutamine:pyruvate aminotransferase
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by SLC3A2, SLC7A10, KYAT1, SLC7A9 and 1 moreextracellular space, cytosolOne of 10 routes

• 11-cis-retinolReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC3A2, SLC7A10, DGAT1, LRAT and 3 moreextracellular space, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. L-Glutamine:pyruvate aminotransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC3A2, SLC7A10, KYAT1, AGXT2extracellular space, cytosol, mitochondrial matrix

• lithocholic acidReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10, GSS, SLCO1A2 and 1 moreextracellular space, cytosolOne of 2 routes

• iodideReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC3A2, SLC7A10, SLC7A5, TPOextracellular space, cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by SLC3A2, SLC7A10, ACLYextracellular space, cytosolOne of 6 routes

• nitric oxideReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC3A2, SLC7A10, SLC7A6, NOS3 and 2 moreextracellular space, cytosolOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC3A2, SLC7A10, SLC7A6, ACY1extracellular space, cytosol

• 2-phenylacetamideReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC3A2, SLC7A10, SLC7A5, EPXextracellular space, cytosol

• D-alanyl-D-alanineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of D-alanine and glutamine (cytosol to extracellular)
  3. Formation of Alanylalanine

  Catalysed by SLC3A2, SLC7A10extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. L-Glutamine:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC3A2, SLC7A10, KYAT1, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A10, SLC7A5, MARS1extracellular space, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC3A2, SLC7A10, SLC7A5, AADATextracellular space, cytosolOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC3A2, SLC7A10, SLC7A5, CNDP2extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC3A2, SLC7A10, SLC7A5, SDS and 1 moreextracellular space, cytosolOne of 6 routes

• tryptamineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC3A2, SLC7A10, SLC7A5, DDCextracellular space, cytosol

• formaldehydeReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase
  3. sarcosine:oxygen oxidoreductase (demethylating)

  Catalysed by SLC3A2, SLC7A10, GNMT, PIPOX and 1 moreextracellular space, cytosol, peroxisomeOne of 2 routes

• creatineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by SLC3A2, SLC7A10, GATM, GAMTextracellular space, cytosolOne of 2 routes

• N-acetyl-L-aspartateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC3A2, SLC7A10, SLC7A13, NAT8Lextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• bilirubin IXalphaReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10, GSS, SLCO1A2 and 1 moreextracellular space, cytosolOne of 2 routes

• oxalic acidReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10, SLC6A14, SLC26A6extracellular space, cytosolOne of 3 routes

• taurolithocholateReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10, GSS, SLCO1A2 and 1 moreextracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)
  3. D-serine + O2 + H2O = 3-hydroxypyruvate + H2O2 + NH4(+)

  Catalysed by SLC3A2, SLC7A10, SLC1A5, DAOextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• CHEBI:17208Reach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by SLC3A2, SLC7A10, GSSextracellular space, cytosol

• homocysteineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Formation of Homocystine

  Catalysed by SLC3A2, SLC7A10, GSSextracellular space, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by SLC3A2, SLC7A10, SLC7A6, OATextracellular space, cytosol, mitochondrial matrix

• anilineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLC3A2, SLC7A10, NAT2, NAT1extracellular space, cytosol

• CHEBI:17312Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

• sulfiteReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC3A2, SLC7A10, GSS, TSTD1extracellular space, cytosolOne of 2 routes

• CHEBI:17380Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC3A2, SLC7A10, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC3A2, SLC7A10, SLC7A5, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC3A2, SLC7A10, SLC7A6extracellular space, cytosol, mitochondrial matrix

• AH2Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. L-Glutamine:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC3A2, SLC7A10, KYAT1, MOCOSextracellular space, cytosolOne of 4 routes

• indole-3-pyruvateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC3A2, SLC7A10, SLC7A5, IL4I1extracellular space, cytosolOne of 3 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SLC3A2, SLC7A10, HADHA, ACADVL and 1 moreextracellular space, cytosol, mitochondrial matrix

• CHEBI:17724Reach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase
  3. dimethylglycine dehydrogenase (formaldehyde)

  Catalysed by SLC3A2, SLC7A10, GNMT, PDPR and 1 moreextracellular space, cytosol

• Ala-tRNA(Ala)Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. L-Glutamine:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A10, KYAT1, AARS1extracellular space, cytosol

• glycine betaineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10, SLC6A14, SLC6A12extracellular space, cytosolOne of 3 routes