oxaloacetate

Three steps

• folic acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Folate Transport by Oats

  Catalysed by GOT2, SLC25A14, SLC25A30, SLC22A8 and 1 moremitochondrial matrix, inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosolOne of 6 routes

• selenomethionineReach from here →
  1. Oxaloacetate Decarboxylase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by FAHD1, AGXT2, CTHcytosol

• decanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. Decanoyl-CoA hydrolase

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 4 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:27760Reach from here →
  1. Oxaloacetate Decarboxylase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by FAHD1, AGXT2, CTHcytosol

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• 5-hydroxytryptophanReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by GOT2, SLC7A13, TPH1, TPH2mitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• hexacosan-1-olReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 3-mercaptolactic acidReach from here →
  1. Oxaloacetate Decarboxylase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by FAHD1, MPST, LDHB, LDHC and 2 morecytosol

• CHEBI:28666Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. LTD4 hydrolysis

  Catalysed by CS, ZDHHC11B, NAA10, ESCO2 and 29 moremitochondrial matrix, cytosolOne of 2 routes

• O-decanoyl-(R)-carnitineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 5 moremitochondrial matrix, cytosol

• 17alpha-hydroxypregnenoloneReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space, endoplasmic reticulum

• pyridoxine 5'-phosphateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GOT2, AGXT2, SCLYmitochondrial matrix, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by GOT2, SLC7A13, CTHmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• CHEBI:28862Reach from here →
  1. GTP:oxaloacetate carboxy-lyase (adding GTP
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dADP to dATP conversion

  Catalysed by PCK1, PKM, PKLRcytosol, mitochondrial matrixOne of 13 routes

• N-acetyl-L-cysteineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CS, NAGSmitochondrial matrix

• a dicarboxylateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by GOT2, SLC25A14, SLC25A30, SLC25A35 and 1 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-glycoloylneuraminateReach from here →
  1. Oxaloacetate Decarboxylase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

  Catalysed by FAHD1, NPLcytosol

• a carboxylateReach from here →
  1. Oxaloacetate Decarboxylase
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by FAHD1cytosol

• Ca(2+)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. transport of aspartate (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by GOT2, SLC1A7, SLC1A3, SLC1A2 and 7 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• Cys-tRNA(Cys)Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by CS, NAGS, CARS1mitochondrial matrix, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GOT2, SLC7A13, FARSB, FARSAmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by GOT2, SLC7A13, WARS1mitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by GOT2, SLC7A13, QARS1mitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by GOT2, ASNS, NARS1mitochondrial matrix, cytosol

• chlorine(.)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by GOT2, ASNS, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 34 routes

• phosphocholineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by CS, CHAT, PHOSPHO1mitochondrial matrix, nucleusOne of 2 routes

• glycocholateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. propanoyl-CoA C-acyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by CS, ACAA1, SCP2, MYO5B and 1 moremitochondrial matrix, peroxisomeOne of 5 routes

• cholateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. propanoyl-CoA C-acyltransferase
  3. choloyl-CoA hydrolase

  Catalysed by CS, ACAA1, SCP2, MYO5B and 1 moremitochondrial matrix, peroxisome, cytosolOne of 2 routes

• glycolateReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by CLYBL, GRHPRmitochondrial matrix, cytosolOne of 3 routes

• hydrogen sulfideReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by SLC25A10mitochondrial matrix, cytosolOne of 5 routes

• D-aspartateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  3. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

  Catalysed by GOT2, SLC1A7, SLC1A3, SLC1A2 and 2 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

• (9Z,12Z)-octadecadienoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 9 moremitochondrial matrix, cytosol

• CHEBI:30249Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by GOT2, SLC7A13, IDO1, TDO2 and 1 moremitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• 3-acetamidopropanalReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)

  Catalysed by CS, PAOX, SMOXmitochondrial matrix, cytosolOne of 4 routes

• oxalateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by GOT2, SLC25A14, SLC25A30, SLC26A2 and 2 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• malonic acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by GOT2, SLC25A14, SLC25A30, SLC25A10mitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• tetradecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. Myristoyl-CoA hydrolase

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 10 moremitochondrial matrix, cytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CS, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• adipic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Activation of adipic acid for Formation of Adipoyl Carnitine
  3. Thioesterification of adipoyl-CoA for Release into Cytosol

  Catalysed by CS, ACOT8mitochondrial matrix, cytosol, peroxisomeOne of 3 routes

• (S)-dihydroorotateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  3. (S)-dihydroorotate amidohydrolase

  Catalysed by GOT2, CADmitochondrial matrix, cytosolOne of 3 routes

• glutarateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Production of Glutaryl Carnitine
  3. glutaryl-CoA + H2O = glutarate + CoA + H(+)

  Catalysed by CS, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosolOne of 5 routes

• (2R,3R)-tartrateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by GOT2, SLC25A14, SLC25A30mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by GOT2, SLC25A14, SLC25A30mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by GOT2, SLC25A14, SLC25A30mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by GOT2, SLC25A14, SLC25A30mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• docosan-1-olReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. docosanoyl-CoA + 2 NADPH + 2 H(+) = docosan-1-ol + 2 NADP(+) + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• hexacosanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. Hexacosanoyl-CoA hydrolase

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• tetracosanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. Tetracosenoyl-CoA hydrolase

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 4 routes