(9Z,12Z)-octadecadienoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

348 compounds within 3 steps: 13 in 1, 47 in 2, 288 in 3

One step

AReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by PTGS2One of 6 routes
13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by PTGS2
9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by PTGS2
11-hydroxy-(9Z,12Z)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + reduced [NADPH--hemoprotein reductase] + O2 = 11-hydroxy-(9Z,12Z)-octadecadienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP1A2, CYP3A4
(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + reduced [NADPH--hemoprotein reductase] + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP2C9One of 2 routes
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
Catalysed by ACSL3, ACSBG2, SLC27A3
(13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
Catalysed by ALOX15, ALOX12
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by PTGS1, PTGS2
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + reduced [NADPH--hemoprotein reductase] + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP2C9One of 2 routes
1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerolReach from here →
1. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
Catalysed by PLA2G6, PNPLA8
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserineReach from here →
1. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + (9Z,12Z)-octadecadienoate + H(+)
Catalysed by ABHD16A
13-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate
Catalysed by ALOX15B
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by PTGS1, PTGS2

Two steps

CHEBI:1146900Reach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (6Z,9Z)-octadecadienoyl-CoA hydrolase
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 4 morecytosolOne of 14 routes
11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoateReach from here →
1. (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate
Catalysed by ALOX15, ALOX12, ALOXE3

1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3

N-(9Z,12Z-octadecadienoyl)-glycineReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, GLYATL2

betaine aldehydeReach from here →

Catalysed by PTGS2, CHDH

oxaloacetateReach from here →

Catalysed by PTGS2, D2HGDH

formaldehydeReach from here →

Catalysed by PTGS2, KDM1A, KDM1BOne of 3 routes

ferrocytochrome cReach from here →

Catalysed by ALOX15, ALOX12cytosol

S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, NUDT19

all-trans-retinolReach from here →

Catalysed by PTGS2, RETSAT

linoleic acidReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 4 morecytosol

AH2Reach from here →

Catalysed by PTGS2, AIFM1, PYROXD1One of 19 routes

L-cysteineReach from here →

Catalysed by PTGS2, MOCOS

(7Z,10Z)-hexadecadienoyl-CoAReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, HADHA and 2 moremitochondrial matrix

nonanoateReach from here →

Catalysed by ALOX15, ALOX12cytosol

cholesteryl (9Z,12Z)-octadecadienoateReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, SOAT2 and 1 moreendoplasmic reticulumOne of 2 routes

(6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, FADS1 and 1 morecytosolOne of 3 routes

octanoyl-CoAReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, ACADM and 1 moremitochondrial matrixOne of 2 routes

7,8-dihydrofolateReach from here →

Catalysed by PTGS2, MTO1

glutathione disulfideReach from here →

Catalysed by ALOX15, ALOX12, GPX1, GSTA1 and 2 more

an acyl-CoAReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3cytosol

1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3

a 2,3-dehydroacyl-CoAReach from here →

Catalysed by PTGS2, ACAD10

(9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →

Catalysed by PTGS2, PTGS1cytosol

Fe(II)-heme aReach from here →

Catalysed by PTGS2, COX15

Mo-molybdopterinReach from here →

Catalysed by PTGS2, MOCOS

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, LCLAT1

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, LCLAT1

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3 and 2 more

(9Z,12Z)-octadecadien-1-olReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, FAR1

(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, ELOVL7 and 3 more

1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, GPAT3 and 3 morecytosolOne of 2 routes

1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, AGPAT2 and 5 more

1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3

1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serineReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3 and 1 more

1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →

Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3