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Proteins/UNIPROT:O14734
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation..
(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression..
Function from UniProtKB (O14734), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
112 statements
112 statements · 7 reference databases · Subject: ACOT8 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
73 reactions
MAM00279c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01219c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or
14 names
Resolves to: ACOT8
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01065CC BY 4.0Reference data
MAM01219c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01176c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01066CC BY 4.0Reference data
MAM01176c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01055c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 11 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01067CC BY 4.0Reference data
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00310c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01068CC BY 4.0Reference data
MAM00310c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00259c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01069CC BY 4.0Reference data
MAM00259c+ATP+CHEBI:1146900+proton+2water+NAD(+)+dioxygenMAM01210c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01070CC BY 4.0Reference data
proton+water+MAM02652xCHEBI:1146900+MAM02651x
Reaction pageLeft to rightUnbalancedEC 3.1.2.27, 2.3.1.65peroxisome
Human-GEM MAR01302CC BY 4.0Reference data
CHEBI:15519+watercholate+CHEBI:1146900+proton
Catalysed by ACOT8
Reaction pageLeft to rightBalancedEC 3.1.2.27cytosol
Human-GEM MAR01660CC BY 4.0Reference data
CHEBI:15519+watercholate+CHEBI:1146900+proton
Catalysed by ACOT8
Reaction pageLeft to rightBalancedEC 3.1.2.27peroxisome
Human-GEM MAR01663CC BY 4.0Reference data
CHEBI:28701+waterchenodeoxycholate+CHEBI:1146900+proton
Catalysed by ACOT4 or ACOT8 or BAAT
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR01718CC BY 4.0Reference data
water+octadecanoyl-CoACHEBI:1146900+proton+octadecanoate
Catalysed by ACOT8 or BAAT or ACOT4
Reaction pageReversibleBalancedEC 3.1.2.2peroxisome
Human-GEM MAR02488CC BY 4.0Reference data
eicosanoyl-CoA+waterCHEBI:1146900+eicosanoate+proton
Catalysed by ACOT8 or BAAT or ACOT4
Reaction pageReversibleBalancedEC 3.1.2.2peroxisome
Human-GEM MAR02502CC BY 4.0Reference data