adenosine

Three steps

• CHEBI:16857Reach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• nicotinamideReach from here →
  1. adenosine:phosphate alpha-D-ribosyltransferase
  2. purine nucleoside phosphorylase (nicotinamide)
  3. purine nucleoside phosphorylase (nicotinamide)

  Catalysed by PNPcytosol

• 3-hydroxypyruvateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by PKM, PKLR, AGXTcytosol

• L-isoleucineReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:17203Reach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• aceneuramateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by PKM, PKLR, NPLcytosol

• 5'-deoxyadenosineReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by PKM, PKLR, TYW1B, TYW1cytosol

• sulfiteReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. sulfotransferase (thioredoxin)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 morecytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• uracilReach from here →
  1. Adenosine aminohydrolase
  2. inosine + UMP = uridine + IMP
  3. uridine:phosphate alpha-D-ribosyltransferase

  Catalysed by ADA, ADA2, NT5C2, UPP2 and 1 morecytosolOne of 2 routes

• xanthineReach from here →
  1. Adenosine aminohydrolase
  2. inosine:phosphate alpha-D-ribosyltransferase
  3. hypoxanthine:NAD+ oxidoreductase

  Catalysed by ADA, ADA2, PNP, XDHcytosolOne of 5 routes

• CHEBI:17808Reach from here →
  1. Adenosine aminohydrolase
  2. inosine + UMP = uridine + IMP
  3. uridine/cytidine kinase (ITP)

  Catalysed by ADA, ADA2, NT5C2, UCK2 and 1 morecytosol

• CHEBI:17895Reach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:18019Reach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• L-glutamineReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• dTDPReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. pyruvate kinase (dTDP)

  Catalysed by PKM, PKLRcytosolOne of 3 routes

• dTTPReach from here →
  1. Adenosine Kinase
  2. dADP to dATP conversion
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by NME4, NME6, NME1, NME2 and 2 morecytosol, mitochondrial matrixOne of 3 routes

• thioredoxin disulfideReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxyadenosine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 12 routes

• CHEBI:18381Reach from here →
  1. Adenosine aminohydrolase
  2. ATP:inosine 5'-phosphotransferase
  3. IMP 1,2-hydrolase (decyclizing)

  Catalysed by ADA, ADA2, ATICcytosol, mitochondrial matrix

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol

• dUMPReach from here →
  1. Adenosine Kinase
  2. ATP:dGDP phosphotransferase
  3. thymidine kinase (deoxyuridine)

  Catalysed by NME4, NME6, NME1, NME2 and 2 morecytosolOne of 4 routes

• CHEBI:29052Reach from here →
  1. adenosine:phosphate alpha-D-ribosyltransferase
  2. D-Ribose 1,5-phosphomutase
  3. transketolase (D-xylulose-5-phosphate)

  Catalysed by PNP, PGM2, TKT, TKTL1 and 1 morecytosol

• L-aspartateReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• acetateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 3 morecytosol, extracellular spaceOne of 2 routes

• formic acidReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 3 morecytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by PKM, PKLR, AGXTcytosolOne of 2 routes

• 3-oxopropanoateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by PKM, PKLR, AGXT2cytosol

• D-serineReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by PKM, PKLR, SRRcytosol

• D-glucopyranose 6-phosphateReach from here →
  1. Adenosine Kinase
  2. dADP to dATP conversion
  3. dATP:D-glucose 6-phosphotransferase

  Catalysed by HK1, HK2, HK3, HKDC1cytosol, mitochondrial matrix

• (R)-lactic acidReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by PKM, PKLR, LDHDcytosol

• (S)-lactic acidReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by PKM, PKLR, LDHB, LDHAL6Bcytosol, mitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by PKM, PKLR, RIDAcytosol

• phosphoenolpyruvic acidReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. pyruvate kinase (dTDP)

  Catalysed by PKM, PKLRcytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by PKM, PKLR, NPLcytosol

• D-riboseReach from here →
  1. adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine
  2. alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
  3. D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)

  Catalysed by LACC1, PGM2, RBKS

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. adenosine:phosphate alpha-D-ribosyltransferase
  2. purine nucleoside phosphorylase (nicotinamide)
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by PNP, NQO2cytosol

• 2-deoxy-alpha-D-ribose 1-phosphateReach from here →
  1. Adenosine aminohydrolase
  2. dIMP + inosine = 2'-deoxyinosine + IMP
  3. 2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine

  Catalysed by ADA, ADA2, NT5C2, PNPcytosolOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by PKM, PKLR, FAHD1cytosol

• glycineReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• XMPReach from here →
  1. Adenosine aminohydrolase
  2. ATP:inosine 5'-phosphotransferase
  3. IMP:NAD+ oxidoreductase

  Catalysed by ADA, ADA2, IMPDH2, IMPDH1cytosol, mitochondrial matrixOne of 2 routes

• D-sedoheptulose 7-phosphateReach from here →
  1. adenosine:phosphate alpha-D-ribosyltransferase
  2. D-Ribose 1,5-phosphomutase
  3. transketolase (D-xylulose-5-phosphate)

  Catalysed by PNP, PGM2, TKT, TKTL1 and 1 morecytosol

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. Adenosine aminohydrolase
  2. ATP:inosine 5'-phosphotransferase
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by ADA, ADA2, ADSS2, ADSS1cytosol, mitochondrial matrixOne of 2 routes

• (2R)-3-phospho-glyceroyl phosphateReach from here →
  1. adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine
  2. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
  3. ATP:3-phospho-D-glycerate 1-phosphotransferase

  Catalysed by LACC1, PGM2L1, PGK1, PGK2 and 1 morecytosolOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by PKM, PKLR, MPSTcytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol