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Proteins/UNIPROT:P20839
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Function from UniProtKB (P20839), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
57 statements
57 statements · 7 reference databases · Subject: IMPDH1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
water+CHEBI:17202+NAD(+)proton+NADH(2-)+XMP
Reaction pageLeft to rightBalancedEC 1.1.1.205cytosol
Human-GEM MAR04040CC BY 4.0Reference data
5 names
Resolves to: IMPDH1
Reaction pageDirection not assertedBalanced
Rhea RHEA:11708CC BY 4.0Reference data