Metabolism of steroids

Steroids, defined by a four-ring cyclopenta[a]phenanthrene carbon skeleton, include cholesterol and bile acids and salts, steroid hormones, and vitamin D, three groups of molecules synthesized from it. In this module, pathways for the synthesis of cholesterol from HMG-CoA (hydroxymethylglutaryl-coenzyme A), and for its conversion to bile acids and salts, steroid hormones, and vitamin D are annotated, together with the SREBP-mediated regulatory process that normally links the rate of cholesterol synthesis to levels of cellular cholesterol.

Summary from Reactome (R-HSA-8957322), read 2026-09-23.