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Proteins/UNIPROT:Q96RS0
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation..
Function from UniProtKB (Q96RS0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
83 statements
83 statements · 4 reference databases · Subject: TGS1 · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome
4 reactions
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA+S-adenosyl-L-methioninea 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA+S-adenosyl-L-homocysteine+hydron
Catalysed by TGS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:78471CC BY 4.0Reference data
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA+S-adenosyl-L-methioninea 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA+S-adenosyl-L-homocysteine+
9 names
Resolves to: TGS1
Catalysed by TGS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:78475CC BY 4.0Reference data
a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA+S-adenosyl-L-methioninea 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA+S-adenosyl-L-homocysteine+hydron
Catalysed by TGS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:78479CC BY 4.0Reference data
a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA+S-adenosyl-L-methioninea 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA+S-adenosyl-L-homocysteine+hydron
Catalysed by TGS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:78507CC BY 4.0Reference data