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Proteins/UNIPROT:P11473
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites..
Function from UniProtKB (P11473), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
195 statements
195 statements · 4 reference databases · Subject: VDR · Sources: gene ontology, Hetionet, Reactome, WikiPathways
3 names
Resolves to: VDR