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Proteins/UNIPROT:Q8NBQ5
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
Function from UniProtKB (Q8NBQ5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
349 statements
349 statements · 6 reference databases · Subject: HSD17B11 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea · Rows fetched: 300
12 reactions
16 names
Resolves to: HSD17B11
Human-GEM MAR01098CC BY 4.0Reference data
MAM00747r+proton+NADPH(4-)MAM01087r+NADP(3-)
Catalysed by HSD17B14 or HSD3B7 or DHRS2 or HTATIP2 or RDH10 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 and 12 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-endoplasmic reticulum
Human-GEM MAR01813CC BY 4.0Reference data
androst-4-ene-3,17-dione+proton+NADPH(4-)NADP(3-)+testosterone
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B3 or HSD17B7 or AKR1C3 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64cytosol
Human-GEM MAR01973CC BY 4.0Reference data
androst-4-ene-3,17-dione+proton+NADPH(4-)NADP(3-)+testosterone
Catalysed by HSD17B6 or HSD17B1 or HSD17B3 or HSD17B7 or HSD17B12 or AKR1C3 or HSD17B11
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR01974CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62cytosol
Human-GEM MAR02036CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62endoplasmic reticulum
Human-GEM MAR02041CC BY 4.0Reference data
MAM01029c+proton+NADPH(4-)MAM01229c+NADP(3-)
Catalysed by HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or RDH13 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or HSD11B2 or SDR42E2 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06670CC BY 4.0Reference data
4-methyl-2-oxopentanoate+proton+NADH(2-)2-hydroxy-4-methylvaleric acid+NAD(+)
Catalysed by DHRS2 or HTATIP2 or MDH1B or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or SDR42E2 or SDR42E1 or WWOX and 6 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06925CC BY 4.0Reference data
estrone+proton+NADH(2-)17beta-estradiol+NAD(+)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR07968CC BY 4.0Reference data
MAM00799m+NADP(3-)proton+NADPH(4-)+MAM03168m
Catalysed by DHRS2 or HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR42E2 or SDR42E1 or WWOX and 7 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-mitochondrial matrix
Human-GEM MAR09804CC BY 4.0Reference data