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Proteins/UNIPROT:P11511
A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)..
Function from UniProtKB (P11511), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · metabolized by
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
50 statements
50 statements · 8 reference databases · Subject: CYP19A1 · Sources: gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
22 reactions
2proton+dioxygen+testosteroneMAM00432c+water
Catalysed by CYP19A1
Reaction pageLeft to rightUnbalancedEC 1.14.14.1cytosol
Human-GEM MAR02029CC BY 4.0Reference data
MAM00432c+2proton+dioxygen19-oxotestosterone+2water
Catalysed by CYP19A1
7 names
Resolves to: CYP19A1
Human-GEM MAR02030CC BY 4.0Reference data
19-oxotestosterone+NADPH(4-)+dioxygen17beta-estradiol+formic acid+water+NADP(3-)
Catalysed by CYP19A1
Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol
Human-GEM MAR02031CC BY 4.0Reference data
androst-4-ene-3,17-dione+2proton+dioxygen19-hydroxyandrost-4-ene-3,17-dione+water
Catalysed by CYP19A1
Reaction pageLeft to rightUnbalancedEC 1.14.14.1cytosol
Human-GEM MAR02032CC BY 4.0Reference data
19-hydroxyandrost-4-ene-3,17-dione+2proton+dioxygen19-oxo-androst-4-ene-3,17-dione+2water
Catalysed by CYP19A1
Reaction pageLeft to rightUnbalancedEC 1.14.14.1cytosol
Human-GEM MAR02033CC BY 4.0Reference data
19-oxo-androst-4-ene-3,17-dione+NADPH(4-)+dioxygenestrone+formic acid+water+NADP(3-)
Catalysed by CYP19A1
Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol
Human-GEM MAR02034CC BY 4.0Reference data
17beta-estradiol+proton+NADPH(4-)+dioxygen2-hydroxy-17beta-estradiol+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP19A1 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 and 13 more alternatives
Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol
Human-GEM MAR02042CC BY 4.0Reference data
17beta-estradiol+proton+NADPH(4-)+dioxygen2-hydroxy-17beta-estradiol+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2E1 or CYP19A1 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 or CYP2U1 and 13 more alternatives
Reaction pageLeft to rightBalancedEC 1.14.14.1endoplasmic reticulum
Human-GEM MAR02043CC BY 4.0Reference data
estrone+proton+NADPH(4-)+dioxygen16alpha-hydroxyestrone+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2E1 or CYP2J2 or CYP19A1 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol
Human-GEM MAR02053CC BY 4.0Reference data
estrone+proton+NADPH(4-)+dioxygen16alpha-hydroxyestrone+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP19A1 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.14.14.1endoplasmic reticulum
Human-GEM MAR02054CC BY 4.0Reference data
androst-4-ene-3,17-dione+NADPH(4-)+2dioxygenestrone+formic acid+2water+NADP(3-)
Catalysed by CYP19A1
Reaction pageLeft to rightBalancedEC 1.14.14.14endoplasmic reticulum
Human-GEM MAR07940CC BY 4.0Reference data
NADPH(4-)+2dioxygen+testosterone17beta-estradiol+formic acid+2water+NADP(3-)
Catalysed by CYP19A1
Reaction pageLeft to rightBalancedEC 1.14.14.14endoplasmic reticulum
Human-GEM MAR07941CC BY 4.0Reference data