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Proteins/UNIPROT:P37058
Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms..
Function from UniProtKB (P37058), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
31 statements
31 statements · 6 reference databases · Subject: HSD17B3 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
11 reactions
androst-4-ene-3,17-dione+proton+NADPH(4-)NADP(3-)+testosterone
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B3 or HSD17B7 or AKR1C3 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64cytosol
Human-GEM MAR01973CC BY 4.0Reference data
7 names
Resolves to: HSD17B3
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR01974CC BY 4.0Reference data
testosterone+NADP(3-)androst-4-ene-3,17-dione+NADPH(4-)+hydron
Catalysed by AKR1B15 or HSD17B1 or AKR1C4 or HSD17B3 or AKR1C3 or AKR1C2 or AKR1C1 or DHRS1
Reaction pageRight to leftBalanced
Rhea RHEA:14981CC BY 4.0Reference data
17beta-estradiol+NADP(3-)estrone+NADPH(4-)+hydron
Catalysed by AKR1B15 or HSD17B6 or HSD17B1 or AKR1C4 or HSD17B3 or AKR1C3 or AKR1C2 or HSD17B7 or AKR1C1 or HSD17B12 or DHRS11 or HSD17B11
Reaction pageRight to leftBalanced
Rhea RHEA:24616CC BY 4.0Reference data
17beta-hydroxy-5alpha-androstan-3-one+NADP(3-)5alpha-androstan-3,17-dione+NADPH(4-)+hydron
Catalysed by AKR1B15 or HSD17B3 or AKR1C1
Reaction pageRight to leftBalanced
Rhea RHEA:42120CC BY 4.0Reference data
androsterone+NADPH(4-)+hydron5alpha-androstane-3alpha,17beta-diol+NADP(3-)
Catalysed by AKR1B15 or HSD17B3 or AKR1C3 or AKR1C1
Reaction pageLeft to rightBalanced
Rhea RHEA:42156CC BY 4.0Reference data
3beta-hydroxyandrost-5-en-17-one+NADPH(4-)+hydronandrost-5-en-3beta,17beta-diol+NADP(3-)
Catalysed by AKR1B15 or HSD17B3
Reaction pageLeft to rightBalanced
Rhea RHEA:46628CC BY 4.0Reference data
3beta-hydroxy-5alpha-androstan-17-one+NADPH(4-)+hydronCHEBI:18329+NADP(3-)
Catalysed by HSD17B3
Reaction pageLeft to rightBalanced
Rhea RHEA:53480CC BY 4.0Reference data
androst-4-ene-3,11,17-trione+NADPH(4-)+hydronCHEBI:34133+NADP(3-)
Catalysed by HSD17B3 or AKR1C3 or AKR1D1 or DHRS11
Reaction pageLeft to rightBalanced
Rhea RHEA:53484CC BY 4.0Reference data
11beta-hydroxyandrost-4-ene-3,17-dione+NADPH(4-)+hydron11beta,17beta-dihydroxyandrost-4-ene-3-one+NADP(3-)
Catalysed by HSD17B3
Reaction pageLeft to rightBalanced
Rhea RHEA:53488CC BY 4.0Reference data
CHEBI:35343+NADP(3-)CHEBI:19168+NADPH(4-)+hydron
Catalysed by HSD17B3 or AKR1C3 or AKR1C1 or DHRS11
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:69284CC BY 4.0Reference data