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Proteins/UNIPROT:P37268
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway..
Function from UniProtKB (P37268), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
366 statements
366 statements · 7 reference databases · Subject: FDFT1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
10 reactions
2(2E,6E)-farnesyl diphosphatediphosphate(3-)+presqualene diphosphate
Catalysed by FDFT1
Reaction pageLeft to rightBalancedEC 2.5.1.21cytosol
Human-GEM MAR01465CC BY 4.0Reference data
proton+NADPH(4-)+presqualene diphosphateNADP(3-)+diphosphate(3-)+squalene
Catalysed by FDFT1
5 names
Resolves to: FDFT1
Human-GEM MAR01467CC BY 4.0Reference data
2(2E,6E)-farnesyl diphosphate+proton+NADPH(4-)NADP(3-)+2diphosphate(3-)+squalene
Catalysed by FDFT1
Reaction pageLeft to rightBalancedEC 2.5.1.21endoplasmic reticulum
Human-GEM MAR01715CC BY 4.0Reference data
2(2E,6E)-farnesyl diphosphatediphosphate(3-)+presqualene diphosphate
Catalysed by FDFT1
Reaction pageLeft to rightBalancedEC 2.5.1.21endoplasmic reticulum
Human-GEM MAR02026CC BY 4.0Reference data
proton+NADPH(4-)+presqualene diphosphateNADP(3-)+diphosphate(3-)+squalene
Catalysed by FDFT1
Reaction pageLeft to rightBalancedEC 2.5.1.21endoplasmic reticulum
Human-GEM MAR02147CC BY 4.0Reference data
presqualene diphosphate+NADH(2-)+hydronsqualene+diphosphate(3-)+NAD(1-)
Catalysed by FDFT1
Reaction pageLeft to rightBalanced
Rhea RHEA:22228CC BY 4.0Reference data
presqualene diphosphate+NADPH(4-)+hydronsqualene+diphosphate(3-)+NADP(3-)
Catalysed by FDFT1
Reaction pageLeft to rightBalanced
Rhea RHEA:22232CC BY 4.0Reference data
2(2E,6E)-farnesyl diphosphatepresqualene diphosphate+diphosphate(3-)
Catalysed by FDFT1
Reaction pageLeft to rightBalanced
Rhea RHEA:22672CC BY 4.0Reference data
2(2E,6E)-farnesyl diphosphate+NADPH(4-)+hydronsqualene+2diphosphate(3-)+NADP(3-)
Catalysed by FDFT1
Reaction pageLeft to rightBalanced
Rhea RHEA:32295CC BY 4.0Reference data
2(2E,6E)-farnesyl diphosphate+NADH(2-)+hydronsqualene+2diphosphate(3-)+NAD(1-)
Catalysed by FDFT1
Reaction pageLeft to rightBalanced
Rhea RHEA:32299CC BY 4.0Reference data