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Proteins/UNIPROT:Q9H4L5
Lipid transfer protein that mediates the non-vesicular transport of phosphoinositide 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), or PI(4)P) at the plasma membrane (PM)/ endoplasmic reticulum (ER) contact sites. Extracts PI4P from the PM, in exchange for phosphatidylcholine. Can bind to the ER membrane protein VAPA and recruit VAPA to PM sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol..
Function from UniProtKB (Q9H4L5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 4 reference databases · Subject: OSBPL3 · Sources: Hetionet, Human Protein Atlas, Reactome, Rhea
1 reaction
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+a 1,2-diacyl-sn-glycero-3-phosphocholinea 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+a 1,2-diacyl-sn-glycero-3-phosphocholine
Transported by OSBPL3
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:85491CC BY 4.0Reference data
6 names
Resolves to: OSBPL3