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Proteins/UNIPROT:Q6P4F2
Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis (By similarity). This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner (By similarity). Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly (By similarity). Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6..
Function from UniProtKB (Q6P4F2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
2 rows
96 statements
96 statements · 4 reference databases · Subject: FDX2 · Sources: Hetionet, Human-GEM, Reactome, UniProt
2 reactions
3 names
Resolves to: FDX2
Human-GEM MAR20184CC BY 4.0Reference data
2L-cysteine+2iron(2+)+NADPH(4-)2L-alanine+proton+NADP(3-)+di-mu-sulfido-diiron(2+)
Catalysed by NDUFAB1 & FDXR & FXN & FDX2 & ISCU & LYRM4 & NFS1
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR20185CC BY 4.0Reference data