Loading the page.
Proteins/UNIPROT:O95342
Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion..
Function from UniProtKB (O95342), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
53 statements
53 statements · 8 reference databases · Subject: ABCB11 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
75 reactions
ATP+glycocholate+waterADP+glycocholate+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC4 or SLC51A or SLC51B or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01868CC BY 4.0Reference data
2 names
Resolves to: ABCB11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01870CC BY 4.0Reference data
ATP+water+taurochenodeoxycholateADP+proton+phosphate(3-)+taurochenodeoxycholate
Transported by ABCB11 or ABCC1 or ABCC3 or ABCC4 or SLC51A or SLC51B
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01872CC BY 4.0Reference data
ATP+glycochenodeoxycholic acid+waterADP+glycochenodeoxycholic acid+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC4 or SLC51A or SLC51B
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01874CC BY 4.0Reference data
ATP+cholate+waterADP+cholate+proton+phosphate(3-)
Transported by ABCB11 or ABCC3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08658CC BY 4.0Reference data
ATP+water+lithocholic acidADP+proton+lithocholic acid+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC11
Reaction pageLeft to rightBalancedEC 6.3.2.11cytosol, extracellular space
Human-GEM MAR10010CC BY 4.0Reference data
deoxycholate+ATP+waterdeoxycholate+ADP+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10014CC BY 4.0Reference data
ATP+water+taurodeoxycholateADP+proton+phosphate(3-)+taurodeoxycholate
Transported by ABCB11 or ABCC3 or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10020CC BY 4.0Reference data
ATP+water+MAM10021cADP+proton+phosphate(3-)+MAM10021e
Transported by ABCB11 or ABCC3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10073CC BY 4.0Reference data
ATP+water+MAM10022cADP+proton+phosphate(3-)+MAM10022e
Transported by ABCB11 or ABCC3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10075CC BY 4.0Reference data
ATP+water+MAM10024cADP+proton+phosphate(3-)+MAM10024e
Transported by ABCB11 or ABCC3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10079CC BY 4.0Reference data
ATP+water+MAM10025cADP+proton+phosphate(3-)+MAM10025e
Transported by ABCB11 or ABCC3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10082CC BY 4.0Reference data