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Proteins/UNIPROT:P48449
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency..
Function from UniProtKB (P48449), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
47 statements
47 statements · 6 reference databases · Subject: LSS · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
(S)-2,3-epoxysqualenelanosterol
Catalysed by LSS
Reaction pageLeft to rightBalancedEC 5.4.99.7cytosol
Human-GEM MAR01473CC BY 4.0Reference data
(S)-2,3-epoxysqualenelanosterol
Catalysed by LSS
Reaction pageLeft to rightBalancedEC 5.4.99.7endoplasmic reticulum
Human-GEM MAR01498CC BY 4.0Reference data
(S)-2,3-epoxysqualenelanosterol
Catalysed by
4 names
Resolves to: LSS
Reaction pageLeft to rightBalanced
Rhea RHEA:14621CC BY 4.0Reference data