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Proteins/UNIPROT:Q15392
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis..
Function from UniProtKB (Q15392), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
159 statements
159 statements · 9 reference databases · Subject: DHCR24 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
11 reactions
desmosterol+FADH2CHEBI:1307929+FAD
Catalysed by DHCR24
Reaction pageLeft to rightBalancedEC 2.3.1.42endoplasmic reticulum
Human-GEM MAR00222CC BY 4.0Reference data
desmosterol+proton+NADPH(4-)CHEBI:1307929+NADP(3-)
Catalysed by DHCR24
Reaction pageLeft to rightBalancedEC 1.3.1.72cytosol
6 names
Resolves to: DHCR24
Human-GEM MAR01526CC BY 4.0Reference data
MAM01066c+proton+NADPH(4-)lathosterol+NADP(3-)
Catalysed by DHCR24
Reaction pageLeft to rightBalancedEC 1.3.1.72cytosol
Human-GEM MAR01533CC BY 4.0Reference data
proton+lanosterol+NADPH(4-)24,25-dihydrolanosterol+NADP(3-)
Catalysed by DHCR24
Reaction pageLeft to rightBalancedEC 1.3.1.72cytosol
Human-GEM MAR01535CC BY 4.0Reference data
proton+NADPH(4-)+MAM03158cMAM01449c+NADP(3-)
Catalysed by DHCR24
Reaction pageLeft to rightBalancedEC 1.3.1.72cytosol
Human-GEM MAR01570CC BY 4.0Reference data
lathosterol+NADP(3-)MAM01066r+proton+NADPH(4-)
Catalysed by DHCR24
Reaction pageReversibleBalancedEC 1.3.1.72endoplasmic reticulum
Human-GEM MAR02206CC BY 4.0Reference data
proton+NADPH(4-)+MAM03158rMAM01449r+NADP(3-)
Catalysed by DHCR24
Reaction pageReversibleBalancedEC 1.3.1.72endoplasmic reticulum
Human-GEM MAR02337CC BY 4.0Reference data
desmosterol+proton+NADPH(4-)CHEBI:1307929+NADP(3-)
Catalysed by DHCR24
Reaction pageLeft to rightBalancedEC 1.3.1.72endoplasmic reticulum
Human-GEM MAR08218CC BY 4.0Reference data
lanosterol+NADPH(4-)+hydron24,25-dihydrolanosterol+NADP(3-)
Catalysed by DHCR24
Reaction pageLeft to rightBalanced
Rhea RHEA:33919CC BY 4.0Reference data
cholesterol+NADP(3-)desmosterol+NADPH(4-)+hydron
Catalysed by DHCR24
Reaction pageRight to leftBalanced
Rhea RHEA:36391CC BY 4.0Reference data
CHEBI:16608+NADP(3-)CHEBI:18252+NADPH(4-)+hydron
Catalysed by DHCR24
Reaction pageRight to leftBalanced
Rhea RHEA:36399CC BY 4.0Reference data