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Proteins/UNIPROT:C9JRZ8
[Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism..
[Isoform 2]: No oxidoreductase activity observed with the tested substrates..
Function from UniProtKB (C9JRZ8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 3 reference databases · Subject: AKR1B15 · Sources: Human-GEM, Reactome, Rhea
18 reactions
3 names
Resolves to: AKR1B15
Human-GEM MAR01098CC BY 4.0Reference data
MAM00747r+proton+NADPH(4-)MAM01087r+NADP(3-)
Catalysed by HSD17B14 or HSD3B7 or DHRS2 or HTATIP2 or RDH10 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 and 12 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-endoplasmic reticulum
Human-GEM MAR01813CC BY 4.0Reference data
MAM01029c+proton+NADPH(4-)MAM01229c+NADP(3-)
Catalysed by HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or RDH13 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or HSD11B2 or SDR42E2 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06670CC BY 4.0Reference data
4-methyl-2-oxopentanoate+proton+NADH(2-)2-hydroxy-4-methylvaleric acid+NAD(+)
Catalysed by DHRS2 or HTATIP2 or MDH1B or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or SDR42E2 or SDR42E1 or WWOX and 6 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06925CC BY 4.0Reference data
MAM00799m+NADP(3-)proton+NADPH(4-)+MAM03168m
Catalysed by DHRS2 or HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR42E2 or SDR42E1 or WWOX and 7 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-mitochondrial matrix
Human-GEM MAR09804CC BY 4.0Reference data
CHEBI:16605+NADP(3-)CHEBI:15368+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or AKR1A1 or AKR1B1
Reaction pageDirection not assertedBalanced
Rhea RHEA:12168CC BY 4.0Reference data
(2E,6E)-farnesol+NADP(3-)(2E,6E)-farnesal+NADPH(4-)+hydron
Catalysed by AKR1B15
Reaction pageDirection not assertedBalanced
Rhea RHEA:14697CC BY 4.0Reference data
testosterone+NADP(3-)androst-4-ene-3,17-dione+NADPH(4-)+hydron
Catalysed by AKR1B15 or HSD17B1 or AKR1C4 or HSD17B3 or AKR1C3 or AKR1C2 or AKR1C1 or DHRS1
Reaction pageRight to leftBalanced
Rhea RHEA:14981CC BY 4.0Reference data
17beta-estradiol+NADP(3-)estrone+NADPH(4-)+hydron
Catalysed by AKR1B15 or HSD17B6 or HSD17B1 or AKR1C4 or HSD17B3 or AKR1C3 or AKR1C2 or HSD17B7 or AKR1C1 or HSD17B12 or DHRS11 or HSD17B11
Reaction pageRight to leftBalanced
Rhea RHEA:24616CC BY 4.0Reference data
all-trans-retinol+NADP(3-)all-trans-retinal+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or DHRS3 or AKR1B1 or RDH10 or RDH13 or RDH11 or RDH12 or RDH14 or RDH8 or DHRS7
Reaction pageRight to leftBalanced
Rhea RHEA:25033CC BY 4.0Reference data
CHEBI:15688+NADP(3-)CHEBI:16583+NADPH(4-)+hydron
Reaction pageRight to leftBalanced
Rhea RHEA:35607CC BY 4.0Reference data
17beta-hydroxy-5alpha-androstan-3-one+NADP(3-)5alpha-androstan-3,17-dione+NADPH(4-)+hydron
Catalysed by AKR1B15 or HSD17B3 or AKR1C1
Reaction pageRight to leftBalanced
Rhea RHEA:42120CC BY 4.0Reference data