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Proteins/UNIPROT:P14324
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Function from UniProtKB (P14324), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
285 statements
285 statements · 7 reference databases · Subject: FDPS · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
7 reactions
MAM01706x+isopentenyl diphosphate(2E)-geranyl diphosphate+diphosphate(3-)
Catalysed by FDPS
Reaction pageLeft to rightBalancedEC 2.5.1.1peroxisome
Human-GEM MAR00285CC BY 4.0Reference data
(2E)-geranyl diphosphate+isopentenyl diphosphate(2E,6E)-farnesyl diphosphate+diphosphate(3-)
Catalysed by FDPS
Reaction pageLeft to rightBalancedEC 2.5.1.10peroxisome
7 names
Resolves to: FDPS
MAM01706c+isopentenyl diphosphate(2E)-geranyl diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalancedEC 2.5.1.1, 2.5.1.10, 2.5.1.29cytosol
Human-GEM MAR01457CC BY 4.0Reference data
(2E)-geranyl diphosphate+isopentenyl diphosphate(2E,6E)-farnesyl diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalancedEC 2.5.1.1, 2.5.1.10, 2.5.1.29cytosol
Human-GEM MAR01460CC BY 4.0Reference data
MAM01706c+(2E,6E)-farnesyl diphosphatediphosphate(3-)+MAM03026c
Reaction pageLeft to rightBalancedEC 2.5.1.10cytosol
Human-GEM MAR01532CC BY 4.0Reference data
isopentenyl diphosphate+(2E)-geranyl diphosphate(2E,6E)-farnesyl diphosphate+diphosphate(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:19361CC BY 4.0Reference data
isopentenyl diphosphate+CHEBI:57623(2E)-geranyl diphosphate+diphosphate(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:22408CC BY 4.0Reference data