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Proteins/UNIPROT:P51659
Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes..
Function from UniProtKB (P51659), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
451 statements
451 statements · 7 reference databases · Subject: HSD17B4 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
183 reactions
proton+NADPH(4-)+MAM04082rNADP(3-)+MAM03158r
Catalysed by HSD17B4
Reaction pageLeft to rightBalancedEC 4.2.1.17endoplasmic reticulum
Human-GEM MAR00115CC BY 4.0Reference data
4CHEBI:1146900+4FAD+4water+4NAD(+)+palmitoyl-CoA4CHEBI:15351
13 names
Resolves to: HSD17B4
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00759CC BY 4.0Reference data
CHEBI:1146900+FAD+water+NAD(+)+octadecanoyl-CoACHEBI:15351+FADH2+proton+NADH(2-)+palmitoyl-CoA
Catalysed by ACAA1 & HSD17B4 & ACOX1 or ACAA1 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR00777CC BY 4.0Reference data
5CHEBI:1146900+2FAD+(6Z,9Z,12Z)-octadecatrienoyl-CoA+5water+5NAD(+)5CHEBI:15351+2FADH2+5proton+5NADH(2-)+octanoyl-CoA
Catalysed by ACAA1 & HSD17B4 & ACOX1 or ACAA1 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00800CC BY 4.0Reference data
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA+5CHEBI:1146900+FAD+5water+5NAD(+)5CHEBI:15351+FADH2+5proton+5NADH(2-)+octanoyl-CoA
Catalysed by ACAA1 & HSD17B4 & ACOX1 or ACAA1 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00833CC BY 4.0Reference data
CHEBI:1146900+eicosanoyl-CoA+FAD+water+NAD(+)CHEBI:15351+FADH2+proton+NADH(2-)+octadecanoyl-CoA
Catalysed by ACAA1 & HSD17B4 & ACOX1 or ACAA1 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00872CC BY 4.0Reference data
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA+CHEBI:1146900+water+NAD(+)(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA+CHEBI:15351+proton+NADH(2-)
Catalysed by ACAA1 & EHHADH & ACOX1 or ACAA1 & HSD17B4 & ACOX1
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00927CC BY 4.0Reference data
CHEBI:63544+CHEBI:1146900+FAD+water+NAD(+)CHEBI:15351+arachidonoyl-CoA+FADH2+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & ACOX1 or ACAA1 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00952CC BY 4.0Reference data
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA+CHEBI:1146900+FAD+water+NAD(+)(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA+CHEBI:15351+FADH2+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & ACOX1 or ACAA1 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00968CC BY 4.0Reference data
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA+CHEBI:1146900+water+NAD(+)(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA+CHEBI:15351+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & ACOX1 or ACAA1 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00972CC BY 4.0Reference data
2CHEBI:1146900+2FAD+2water+2NAD(+)+tetracosanoyl-CoA2CHEBI:15351+eicosanoyl-CoA+2FADH2+2proton+2NADH(2-)
Catalysed by ACAA1 & HSD17B4 & ACOX1 or ACAA1 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00974CC BY 4.0Reference data
(15Z)-tetracosenoyl-CoA+3CHEBI:1146900+3FAD+3water+3NAD(+)3CHEBI:15351+3FADH2+3proton+3NADH(2-)+oleoyl-CoA
Catalysed by ACAA1 & HSD17B4 & ACOX1 or ACAA1 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedEC 4.2.1.74peroxisome
Human-GEM MAR00975CC BY 4.0Reference data