Proteins/UNIPROT:P02774

GC

ProteinUNIPROT:P02774

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation..

Function from UniProtKB (P02774), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 4 reference databases · Subject: GC · Sources: Hetionet, Human-GEM, Reactome, WikiPathways

Order

GC covaries with BRWD3ProteinHetionet hetionet:covaries:254065-2638Inferred only
GC covaries with CABS1ProteinHetionet hetionet:covaries:2638-85438Inferred only
GC covaries with KRI1ProteinHetionet hetionet:covaries:2638-65095Inferred only
GC covaries with LRRC14ProteinHetionet hetionet:covaries:2638-9684Inferred only
GC covaries with NPHS1ProteinHetionet hetionet:covaries:2638-4868Inferred only
OR10A3 covaries with GCProteinHetionet hetionet:covaries:2638-26496Inferred only
GC covaries with PDE3BProteinHetionet hetionet:covaries:2638-5140Inferred only
GC covaries with ZNF197ProteinHetionet hetionet:covaries:10168-2638Inferred only
GC covaries with ZNF502ProteinHetionet hetionet:covaries:2638-91392Inferred only
GC covaries with ZZEF1ProteinHetionet hetionet:covaries:23140-2638Inferred only
ACTA1 interacts with GCProteinHetionet hetionet:interacts:2638-58Inferred only
GC participates in MetabolismPathwayReactome R-HSA-1430728Inferred only

Show the remaining 6

GC participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
GC participates in Metabolism of steroidsPathwayReactome R-HSA-8957322Inferred only
GC participates in Vitamin D (calciferol) metabolismPathwayReactome R-HSA-196791Inferred only
GC participates in Vitamin D metabolismPathwayWikiPathways WP1531Inferred only
calcidiol is a substrate of GCCompoundHuman-GEM MAR08008Inferred only
calcidiol is a substrate of GCCompoundHuman-GEM MAR02118Inferred only

Reactions

3 reactions

calcidiol+proton+NADPH(4-)+dioxygencalcitriol+water+NADP(3-)
Catalysed by CYP27B1 & CUBN & GC & LRP2
Reaction pageLeft to rightBalancedEC 1.14.15.18cytosol
Human-GEM MAR02118CC BY 4.0Reference data
MAM00620m+proton+NADPH(4-)

Other names

9 names

Resolves to: GC

Also called: DBPDBP-mafGc protein-derived macrophage activating factorGc-globulinGc-MAFGcMAFGroup-specific componentVDBVitamin D-binding protein-macrophage activating factor

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