Proteins/UNIPROT:Q14872

MTF1

ProteinUNIPROT:Q14872

Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals. Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A. Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity)..

Function from UniProtKB (Q14872), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 4 reference databases · Subject: MTF1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

TATDN2 covaries with MTF1ProteinHetionet hetionet:covaries:4520-9797Inferred only
TYW1 covaries with MTF1ProteinHetionet hetionet:covaries:4520-55253Inferred only
MTF1 interacts with AP1M1ProteinHetionet hetionet:interacts:4520-8907Inferred only
EP300 interacts with MTF1ProteinHetionet hetionet:interacts:2033-4520Inferred only
MTF1 participates in Activation of gene expression by SREBF (SREBP)PathwayReactome R-HSA-2426168Inferred only
MTF1 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
MTF1 participates in Copper homeostasisPathwayWikiPathways WP3286Inferred only
MTF1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
MTF1 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
MTF1 participates in Metabolism of steroidsPathwayReactome R-HSA-8957322Inferred only
MTF1 participates in MTF1 activates gene expressionPathwayReactome R-HSA-5660489Inferred only
MTF1 participates in PPARA activates gene expressionPathwayReactome R-HSA-1989781Inferred only

Show the remaining 7

MTF1 participates in Regulation of cholesterol biosynthesis by SREBP (SREBF)PathwayReactome R-HSA-1655829Inferred only
MTF1 participates in Regulation of lipid metabolism by PPARalphaPathwayReactome R-HSA-400206Inferred only
MTF1 participates in Response to metal ionsPathwayReactome R-HSA-5660526Inferred only
MTF1 participates in Zinc homeostasisPathwayWikiPathways WP3529Inferred only
MTF1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q14872|GO:0045944Inferred only
MTF1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q14872|GO:0006357Inferred only
ATP1B1 increases the expression of MTF1ProteinHetionet hetionet:regulates:481-4520Inferred only

Other names

3 names

Resolves to: MTF1

Also called: MRE-binding transcription factorMTF-1Transcription factor MTF-1

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