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Proteins/UNIPROT:Q14973
As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation..
(Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV). The recognition for human SLC10A1/NTCP is highly specific..
Function from UniProtKB (Q14973), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
93 statements
93 statements · 6 reference databases · Subject: SLC10A1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
51 reactions
glycocholate+MAM02357cglycocholate+MAM02357e
Transported by SLC10A1
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR01852CC BY 4.0Reference data
sodium(1+)+taurocholatesodium(1+)+taurocholate
Transported by SLC10A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
6 names
Resolves to: SLC10A1
glycocholate+sodium(1+)glycocholate+sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01862CC BY 4.0Reference data
glycocholate+2sodium(1+)glycocholate+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01863CC BY 4.0Reference data
chenodeoxycholate+2sodium(1+)chenodeoxycholate+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01864CC BY 4.0Reference data
2sodium(1+)+taurocholate2sodium(1+)+taurocholate
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01865CC BY 4.0Reference data
2sodium(1+)+taurochenodeoxycholate2sodium(1+)+taurochenodeoxycholate
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01866CC BY 4.0Reference data
glycochenodeoxycholic acid+2sodium(1+)glycochenodeoxycholic acid+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01867CC BY 4.0Reference data
2sodium(1+)+taurolithocholate2sodium(1+)+taurolithocholate
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05435CC BY 4.0Reference data
glycolithocholic acid+2sodium(1+)glycolithocholic acid+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05436CC BY 4.0Reference data
2sodium(1+)+tauroursodeoxycholate2sodium(1+)+tauroursodeoxycholate
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05437CC BY 4.0Reference data
glycoursodeoxycholate+2sodium(1+)glycoursodeoxycholate+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05438CC BY 4.0Reference data