Loading the page.
Proteins/UNIPROT:P56937
Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis. Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol. Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase..
[Isoform 3]: Does not have enzymatic activities toward E1 and DHT..
Function from UniProtKB (P56937), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
53 statements
53 statements · 5 reference databases · Subject: HSD17B7 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
20 reactions
MAM00809c+3proton+NADP(3-)MAM00968c+NADPH(4-)
Catalysed by HSD17B7
Reaction pageReversibleUnbalancedEC 1.1.1.270cytosol
Human-GEM MAR01500CC BY 4.0Reference data
MAM01067c+proton+NADPH(4-)NADP(3-)+MAM03158c
Catalysed by HSD17B7
Reaction pageLeft to rightBalancedEC 1.1.1.270cytosol
8 names
Resolves to: HSD17B7
Human-GEM MAR01509CC BY 4.0Reference data
MAM00966c+proton+NADPH(4-)MAM00967c+NADP(3-)
Catalysed by HSD17B7
Reaction pageLeft to rightBalancedEC 1.1.1.270cytosol
Human-GEM MAR01547CC BY 4.0Reference data
MAM01068c+proton+NADPH(4-)MAM01449c+NADP(3-)
Catalysed by HSD17B7
Reaction pageLeft to rightBalancedEC 1.1.1.270cytosol
Human-GEM MAR01552CC BY 4.0Reference data
androst-4-ene-3,17-dione+proton+NADPH(4-)NADP(3-)+testosterone
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B3 or HSD17B7 or AKR1C3 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64cytosol
Human-GEM MAR01973CC BY 4.0Reference data
androst-4-ene-3,17-dione+proton+NADPH(4-)NADP(3-)+testosterone
Catalysed by HSD17B6 or HSD17B1 or HSD17B3 or HSD17B7 or HSD17B12 or AKR1C3 or HSD17B11
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR01974CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62cytosol
Human-GEM MAR02036CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62endoplasmic reticulum
Human-GEM MAR02041CC BY 4.0Reference data
MAM00809r+3proton+NADP(3-)MAM00968r+NADPH(4-)
Catalysed by HSD17B7
Reaction pageReversibleUnbalancedEC 1.1.1.270endoplasmic reticulum
Human-GEM MAR02301CC BY 4.0Reference data
estrone+proton+NADH(2-)17beta-estradiol+NAD(+)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR07968CC BY 4.0Reference data
androsterone+proton+NADPH(4-)+1.5dioxygen3beta,16alpha-dihydroxy-androst-5-en-17-one+2water+NADP(3-)
Catalysed by HSD17B7
Reaction pageLeft to rightBalancedEC 1.1.1.270endoplasmic reticulum
Human-GEM MAR07970CC BY 4.0Reference data
CHEBI:18329+NADP(3-)17beta-hydroxy-5alpha-androstan-3-one+NADPH(4-)+hydron
Catalysed by HSD3B1 or AKR1C4 or AKR1C3 or HSD17B7 or AKR1C1
Reaction pageRight to leftBalanced
Rhea RHEA:16297CC BY 4.0Reference data