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Proteins/UNIPROT:Q9HCL2

GPAM

Protein·UNIPROT:Q9HCL2Glycerol-3-phosphate acyltransferase 1, mitochondrial

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Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids. Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid. Has a narrow hydrophobic binding cleft that selects for a linear acyl chain. Catalytic activity is higher for substrates with a 16-carbon acyl chain..

Function from UniProtKB (Q9HCL2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

160 statements

160 statements · 6 reference databases · Subject: GPAM · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

Search this listOrder

GPAM is expressed in adipose tissueAnatomyBgee ENSG00000119927Inferred only
GPAM is expressed in corpus epididymisAnatomyBgee ENSG00000119927Inferred only
GPAM is expressed in liverAnatomyBgee ENSG00000119927Inferred only
GPAM is expressed in pericardiumAnatomyBgee ENSG00000119927Inferred only
GPAM is expressed in right adrenal gland cortexAnatomyBgee ENSG00000119927Inferred only
GPAM is expressed in skin of hipAnatomyBgee ENSG00000119927Inferred only
GPAM is expressed in subcutaneous adipose tissueAnatomyBgee ENSG00000119927Inferred only
GPAM is expressed in synovial jointAnatomyBgee ENSG00000119927Inferred only
GPAM is expressed in vena cavaAnatomyBgee ENSG00000119927Inferred only
APP interacts with GPAMProteinHetionet hetionet:interacts:351-57678Inferred only
UBC interacts with GPAMProteinHetionet hetionet:interacts:57678-7316Inferred only
GPAM participates in Activation of gene expression by SREBF (SREBP)PathwayReactome R-HSA-2426168Inferred only

Show the remaining 148

GPAM participates in Epigenetic regulation by WDR5-containing histone modifying complexesPathwayReactome R-HSA-9917777Inferred only
GPAM participates in Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexesPathwayReactome R-HSA-9851695Inferred only
GPAM participates in Epigenetic regulation of gene expressionPathwayReactome R-HSA-212165Inferred only
GPAM participates in Epigenetic regulation of gene expression by MLL3 and MLL4 complexesPathwayReactome R-HSA-9818564Inferred only
GPAM participates in ESR-mediated signalingPathwayReactome R-HSA-8939211Inferred only
GPAM participates in Estrogen receptor pathwayPathwayWikiPathways WP2881Inferred only
GPAM participates in Estrogen-dependent gene expressionPathwayReactome R-HSA-9018519Inferred only
GPAM participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
GPAM participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
GPAM participates in Glycerolipids and glycerophospholipidsPathwayWikiPathways WP4722Inferred only
GPAM participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
GPAM participates in Glycerophospholipid biosynthetic pathwayPathwayWikiPathways WP2533Inferred only
GPAM participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GPAM participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
GPAM participates in Metabolism of steroidsPathwayReactome R-HSA-8957322Inferred only
GPAM participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
GPAM participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
GPAM participates in MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosisPathwayReactome R-HSA-9841922Inferred only
GPAM participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
GPAM participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
GPAM participates in Regulation of cholesterol biosynthesis by SREBP (SREBF)PathwayReactome R-HSA-1655829Inferred only
GPAM participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
GPAM participates in RUNX1 regulates estrogen receptor mediated transcriptionPathwayReactome R-HSA-8931987Inferred only
GPAM participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GPAM participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
GPAM participates in Sterol regulatory element binding proteins SREBP signalingPathwayWikiPathways WP1982Inferred only
GPAM participates in Synthesis of PAPathwayReactome R-HSA-1483166Inferred only
GPAM participates in Transcriptional regulation by RUNX1PathwayReactome R-HSA-8878171Inferred only
GPAM participates in Triacylglyceride synthesisPathwayWikiPathways WP325Inferred only
GPAM participates in Triglyceride biosynthesisPathwayReactome R-HSA-75109Inferred only
GPAM participates in Triglyceride metabolismPathwayReactome R-HSA-8979227Inferred only
(11Z,14Z,17Z)-eicosatrienoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00530Inferred only
(11Z,14Z)-eicosadienoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00542Inferred only
(11Z)-docosenoyl-CoA(4-) is a substrate of GPAMCompoundHuman-GEM MAR00516Inferred only
(11Z)-eicosenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00509Inferred only
(13Z)-docosenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00515Inferred only
(13Z)-eicosenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00508Inferred only
(15Z)-tetracosenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00519Inferred only
(17Z)-hexacosenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00521Inferred only
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00529Inferred only
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00541Inferred only
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00525Inferred only
(5Z)-tetradecenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00491Inferred only
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00528Inferred only
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00523Inferred only
(6Z,9Z,12Z)-octadecatrienoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00535Inferred only
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00526Inferred only
(7Z)-hexadecenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00495Inferred only
(7Z)-octadecenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00504Inferred only
(7Z)-tetradecenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00490Inferred only
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00524Inferred only
(8Z,11Z,14Z)-eicosatrienoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00536Inferred only
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00527Inferred only
(9Z,12Z,15Z)-octadecatrienoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00522Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAMCompoundRhea RHEA:37203Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00534Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00505Inferred only
(9Z)-heptadecenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00498Inferred only
(9Z)-hexadecenoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00494Inferred only
(9Z)-octadecenoyl-CoA is a substrate of GPAMCompoundRhea RHEA:37199Inferred only
1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) is a substrate of GPAMCompoundRhea RHEA:33203Inferred only
an acyl-CoA is a substrate of GPAMCompoundRhea RHEA:15325Inferred only
an acyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00579Inferred only
an acyl-CoA is a substrate of GPAMCompoundRhea RHEA:33203Inferred only
arachidonoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00537Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00541Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00527Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00486Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00487Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00488Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00489Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00490Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00491Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00492Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00493Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00494Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00495Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00496Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00497Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00498Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00499Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00500Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00501Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00502Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00503Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00504Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00505Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00506Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00507Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00508Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00509Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00510Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00511Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00512Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00513Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00514Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00515Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00516Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00517Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00518Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00519Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00520Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00521Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00522Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00523Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00524Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00525Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00526Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00528Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00529Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00530Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00531Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00532Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00533Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00534Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00535Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00536Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00537Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00538Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00539Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00540Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00542Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00543Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00544Inferred only
CHEBI:15978 is a substrate of GPAMCompoundHuman-GEM MAR00579Inferred only
CHEBI:63544 is a substrate of GPAMCompoundHuman-GEM MAR00538Inferred only
docosanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00514Inferred only
dodecanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00486Inferred only
dodecanoyl-CoA is a substrate of GPAMCompoundRhea RHEA:35727Inferred only
eicosanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00507Inferred only
elaidic acid is a substrate of GPAMCompoundHuman-GEM MAR00503Inferred only
heptadecanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00496Inferred only
hexacosanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00520Inferred only
hexadecanoyl-CoA is a substrate of GPAMCompoundRhea RHEA:35723Inferred only
nonadecanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00506Inferred only
octadecanoyl-CoA is a substrate of GPAMCompoundRhea RHEA:37195Inferred only
octadecanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00499Inferred only
oleoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00502Inferred only
palmitoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00493Inferred only
sn-glycerol 3-phosphate is a substrate of GPAMCompoundRhea RHEA:37203Inferred only
sn-glycerol 3-phosphate is a substrate of GPAMCompoundRhea RHEA:35723Inferred only
sn-glycerol 3-phosphate is a substrate of GPAMCompoundRhea RHEA:15325Inferred only
sn-glycerol 3-phosphate is a substrate of GPAMCompoundRhea RHEA:35727Inferred only
sn-glycerol 3-phosphate is a substrate of GPAMCompoundRhea RHEA:37195Inferred only
sn-glycerol 3-phosphate is a substrate of GPAMCompoundRhea RHEA:37199Inferred only
tetracosanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00518Inferred only
tetradecanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00488Inferred only
tricosanoyl-CoA is a substrate of GPAMCompoundHuman-GEM MAR00517Inferred only

Reactions

67 reactions

dodecanoyl-CoA+CHEBI:159781-dodecanoyl-sn-glycerol 3-phosphate+CHEBI:1146900
Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2
Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol
Human-GEM MAR00486CC BY 4.0Reference data
CHEBI:15978+MAM03050cMAM00502c+CHEBI:1146900
Catalysed by GPAM

Other names

3 names

Resolves to: GPAM

Also called: GPAT-1GPAT1KIAA1560

← Every protein Find it in the graph →

or

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00487CC BY 4.0Reference data

tetradecanoyl-CoA+CHEBI:159781-tetradecanoyl-sn-glycerol 3-phosphate+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00488CC BY 4.0Reference data

MAM00129c+CHEBI:15978MAM00471c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00489CC BY 4.0Reference data

(7Z)-tetradecenoyl-CoA+CHEBI:15978MAM00463c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00490CC BY 4.0Reference data

(5Z)-tetradecenoyl-CoA+CHEBI:15978MAM00454c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00491CC BY 4.0Reference data

MAM02689c+CHEBI:15978MAM00498c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00492CC BY 4.0Reference data

palmitoyl-CoA+CHEBI:159781-hexadecanoyl-sn-glycero-3-phosphate+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00493CC BY 4.0Reference data

(9Z)-hexadecenoyl-CoA+CHEBI:15978MAM00497c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00494CC BY 4.0Reference data

(7Z)-hexadecenoyl-CoA+CHEBI:15978MAM00461c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00495CC BY 4.0Reference data

heptadecanoyl-CoA+CHEBI:15978MAM00481c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00496CC BY 4.0Reference data

MAM00004c+CHEBI:15978MAM00438c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00497CC BY 4.0Reference data

Show the remaining 55