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Proteins/UNIPROT:Q9NYL5
A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)..
Function from UniProtKB (Q9NYL5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
24 statements
24 statements · 6 reference databases · Subject: CYP39A1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
(24S)-hydroxycholesterol+proton+NADPH(4-)+dioxygen(24S)-7alpha-dihydroxycholesterol+water+NADP(3-)
Catalysed by CYP39A1
Reaction pageLeft to rightBalancedEC 1.14.15.15endoplasmic reticulum
Human-GEM MAR01569CC BY 4.0Reference data
3 names
Resolves to: CYP39A1
Catalysed by CYP39A1
Reaction pageLeft to rightBalancedEC 1.14.14.26cytosol
Human-GEM MAR01737CC BY 4.0Reference data
(24S)-hydroxycholesterol+reduced [NADPH--hemoprotein reductase]+dioxygen(24S)-7alpha-dihydroxycholesterol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP7B1 or CYP7A1 or CYP39A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46124CC BY 4.0Reference data