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Proteins/UNIPROT:O75845
Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death..
Function from UniProtKB (O75845), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
154 statements
154 statements · 7 reference databases · Subject: SC5D · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
8 reactions
MAM01066r+proton+NADPH(4-)+dioxygen7-dehydrodesmosterol+2water+NADP(3-)
Catalysed by SC5D
Reaction pageLeft to rightBalancedEC 1.14.19.20endoplasmic reticulum
Human-GEM MAR01508CC BY 4.0Reference data
6 names
Resolves to: SC5D
Reaction pageLeft to rightBalancedEC 1.14.19.20endoplasmic reticulum
Human-GEM MAR01510CC BY 4.0Reference data
MAM01066c+proton+NADPH(4-)+dioxygen7-dehydrodesmosterol+2water+NADP(3-)
Catalysed by SC5D
Reaction pageLeft to rightBalancedEC 1.14.19.20cytosol
Human-GEM MAR01516CC BY 4.0Reference data
proton+lathosterol+NADH(2-)+dioxygen2water+NAD(+)+7-dehydrocholesterol
Catalysed by SC5D
Reaction pageLeft to rightBalancedEC 1.14.19.20cytosol
Human-GEM MAR01557CC BY 4.0Reference data
proton+lathosterol+NADPH(4-)+dioxygen2water+NADP(3-)+7-dehydrocholesterol
Catalysed by SC5D
Reaction pageLeft to rightBalancedEC 1.14.19.20cytosol
Human-GEM MAR01558CC BY 4.0Reference data
lathosterol+2Fe(II)-[cytochrome b5]+dioxygen+2hydron7-dehydrocholesterol+2Fe(III)-[cytochrome b5]+2water
Catalysed by SC5D
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46556CC BY 4.0Reference data
CHEBI:16290+2Fe(II)-[cytochrome b5]+dioxygen+2hydron7-dehydrodesmosterol+2Fe(III)-[cytochrome b5]+2water
Catalysed by SC5D
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47184CC BY 4.0Reference data
CHEBI:138130+2Fe(II)-[cytochrome b5]+dioxygen+2hydronCHEBI:138131+2Fe(III)-[cytochrome b5]+2water
Catalysed by SC5D
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54320CC BY 4.0Reference data