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Proteins/UNIPROT:Q13085
Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA..
Function from UniProtKB (Q13085), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
137 statements
137 statements · 5 reference databases · Subject: ACACA · Sources: Bgee, Hetionet, Reactome, UniProt, WikiPathways
3 reactions
MAM01357c+ATP+hydrogencarbonateADP+MAM01422c+proton+phosphate(3-)
Catalysed by ACACA
Reaction pageLeft to rightBalance undeterminableEC 6.3.4.14cytosol
Human-GEM MAR07672CC BY 4.0Reference data
CHEBI:15351+MAM01422cMAM01357c+malonyl-CoA
Catalysed by ACACA
5 names
Resolves to: ACACA
Human-GEM MAR07673CC BY 4.0Reference data
hydrogencarbonate+acetyl-CoA+ATP(4-)malonyl-CoA+ADP(3-)+hydrogenphosphate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:11308CC BY 4.0Reference data