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Proteins/UNIPROT:Q3L8U1

CHD9

Protein·UNIPROT:Q3L8U1

Open in the graph

Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity)..

Function from UniProtKB (Q3L8U1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

35 statements

35 statements · 2 reference databases · Subject: CHD9 · Sources: Hetionet, Reactome

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ZNF382 covaries with CHD9ProteinHetionet hetionet:covaries:80205-84911Inferred only
ESR1 interacts with CHD9ProteinHetionet hetionet:interacts:2099-80205Inferred only
NR1I3 interacts with CHD9ProteinHetionet hetionet:interacts:80205-9970Inferred only
NR3C1 interacts with CHD9ProteinHetionet hetionet:interacts:2908-80205Inferred only
PPARA interacts with CHD9ProteinHetionet hetionet:interacts:5465-80205Inferred only
RXRA interacts with CHD9ProteinHetionet hetionet:interacts:6256-80205Inferred only
SUMO2 interacts with CHD9ProteinHetionet hetionet:interacts:6613-80205Inferred only
UBC interacts with CHD9ProteinHetionet hetionet:interacts:7316-80205Inferred only
CHD9 participates in Activation of gene expression by SREBF (SREBP)PathwayReactome R-HSA-2426168Inferred only
CHD9 participates in AdipogenesisPathwayReactome R-HSA-9843745Inferred only
CHD9 participates in ATP-dependent chromatin remodelersPathwayReactome R-HSA-9932444Inferred only
CHD9 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionPathwayReactome R-HSA-1368108Inferred only

Show the remaining 23

CHD9 participates in Cellular response to chemical stressPathwayReactome R-HSA-9711123Inferred only
CHD9 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
CHD9 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
CHD9 participates in CHD chromatin remodelersPathwayReactome R-HSA-9937848Inferred only
CHD9 participates in CHD6, CHD7, CHD8, CHD9 subfamilyPathwayReactome R-HSA-9943962Inferred only
CHD9 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
CHD9 participates in Circadian clockPathwayReactome R-HSA-9909396Inferred only
CHD9 participates in Cytoprotection by HMOX1PathwayReactome R-HSA-9707564Inferred only
CHD9 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
CHD9 participates in Expression of BMAL (ARNTL), CLOCK, and NPAS2PathwayReactome R-HSA-9931509Inferred only
CHD9 participates in Heme signalingPathwayReactome R-HSA-9707616Inferred only
CHD9 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CHD9 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
CHD9 participates in Metabolism of steroidsPathwayReactome R-HSA-8957322Inferred only
CHD9 participates in Mitochondrial biogenesisPathwayReactome R-HSA-1592230Inferred only
CHD9 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
CHD9 participates in PPARA activates gene expressionPathwayReactome R-HSA-1989781Inferred only
CHD9 participates in Regulation of cholesterol biosynthesis by SREBP (SREBF)PathwayReactome R-HSA-1655829Inferred only
CHD9 participates in Regulation of lipid metabolism by PPARalphaPathwayReactome R-HSA-400206Inferred only
CHD9 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionPathwayReactome R-HSA-9933387Inferred only
CHD9 participates in Transcriptional activation of mitochondrial biogenesisPathwayReactome R-HSA-2151201Inferred only
CHD9 participates in Transcriptional regulation of white adipocyte differentiationPathwayReactome R-HSA-381340Inferred only
ARHGAP35 increases the expression of CHD9ProteinHetionet hetionet:regulates:2909-80205Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

11 names

Resolves to: CHD9

Also called: CHD-9Chromatin-related mesenchymal modulatorChromatin-remodeling factor CHROM1Chromo domain-containing protein 9CReMMKIAA0308KISH2Kismet homolog 2Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa proteinPPAR-alpha-interacting complex protein 320 kDaPRIC320

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Balanced

Rhea RHEA:13065CC BY 4.0Reference data