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Proteins/UNIPROT:Q9UBM7
Oxidoreductase that catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol (By similarity). Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation..
Together with cholestenol Delta-isomerase/EBP, forms part of the microsomal antiestrogen binding site (AEBS), a multiprotein complex located in the ER membrane. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT). Within this complex, it cooperates in the binding of substrates to ChEH, while EBP carries the catalytic activity..
Function from UniProtKB (Q9UBM7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
182 statements
182 statements · 7 reference databases · Subject: DHCR7 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
7-dehydrodesmosterol+proton+NADPH(4-)desmosterol+NADP(3-)
Catalysed by DHCR7
Reaction pageLeft to rightBalancedEC 1.3.1.21endoplasmic reticulum
Human-GEM MAR00227CC BY 4.0Reference data
proton+NADPH(4-)+7-dehydrocholesterolCHEBI:1307929+NADP(3-)
Catalysed by DHCR7
5 names
Resolves to: DHCR7
Human-GEM MAR00228CC BY 4.0Reference data
7-dehydrodesmosterol+proton+NADPH(4-)desmosterol+NADP(3-)
Catalysed by DHCR7
Reaction pageLeft to rightBalancedEC 1.3.1.21cytosol
Human-GEM MAR01519CC BY 4.0Reference data
proton+NADPH(4-)+7-dehydrocholesterolCHEBI:1307929+NADP(3-)
Catalysed by DHCR7
Reaction pageLeft to rightBalancedEC 1.3.1.21cytosol
Human-GEM MAR01565CC BY 4.0Reference data
7-dehydrodesmosterol+proton+NADPH(4-)desmosterol+NADP(3-)
Catalysed by DHCR7
Reaction pageReversibleBalancedEC 1.3.1.21nucleus
Human-GEM MAR03061CC BY 4.0Reference data
CHEBI:49305+waterCHEBI:28082
Reaction pageLeft to rightBalanced
Rhea RHEA:11964CC BY 4.0Reference data
CHEBI:28164+waterCHEBI:28082
Reaction pageLeft to rightBalanced
Rhea RHEA:15113CC BY 4.0Reference data
cholesterol+NADP(3-)7-dehydrocholesterol+NADPH(4-)+hydron
Catalysed by DHCR7
Reaction pageRight to leftBalanced
Rhea RHEA:23984CC BY 4.0Reference data
7-dehydrodesmosterol+NADPH(4-)+hydrondesmosterol+NADP(3-)
Catalysed by DHCR7
Reaction pageLeft to rightBalanced
Rhea RHEA:46740CC BY 4.0Reference data