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Proteins/UNIPROT:Q07973
A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product. Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin..
Function from UniProtKB (Q07973), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
59 statements
59 statements · 7 reference databases · Subject: CYP24A1 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
21 reactions
calcidiol+proton+NADPH(4-)+dioxygensecalciferol+water+NADP(3-)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16cytosol
Human-GEM MAR02137CC BY 4.0Reference data
6 names
Resolves to: CYP24A1
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16mitochondrial matrix
Human-GEM MAR02138CC BY 4.0Reference data
secalciferol+proton+NADH(2-)+dioxygencalcitetrol+water+NAD(+)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16cytosol
Human-GEM MAR02139CC BY 4.0Reference data
secalciferol+proton+NADH(2-)+dioxygencalcitetrol+water+NAD(+)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16mitochondrial matrix
Human-GEM MAR02140CC BY 4.0Reference data
calcitriol+proton+NADPH(4-)+dioxygencalcitetrol+water+NADP(3-)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16mitochondrial matrix
Human-GEM MAR02141CC BY 4.0Reference data
secalciferol+proton+NADH(2-)+dioxygenMAM00607m+water+NAD(+)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 3.4.24.16mitochondrial matrix
Human-GEM MAR02767CC BY 4.0Reference data
NADPH(4-)+dioxygen+MAM03377mMAM01418m+water+NADP(3-)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16mitochondrial matrix
Human-GEM MAR03436CC BY 4.0Reference data
MAM00620m+proton+NADPH(4-)+dioxygenMAM00613m+water+NADP(3-)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16mitochondrial matrix
Human-GEM MAR07999CC BY 4.0Reference data
calcitriol+2reduced [adrenodoxin]+dioxygen+2hydroncalcitetrol+2oxidized [adrenodoxin]+water
Catalysed by CYP24A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24964CC BY 4.0Reference data
calcidiol+2reduced [adrenodoxin]+dioxygen+2hydronsecalciferol+2oxidized [adrenodoxin]+water
Catalysed by CYP24A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24968CC BY 4.0Reference data
calcitetrol+2reduced [adrenodoxin]+dioxygen+2hydron(1S)-1,25-dihydroxy-24-oxocalciol+2oxidized [adrenodoxin]+2water
Catalysed by CYP24A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24972CC BY 4.0Reference data
(1S)-1,25-dihydroxy-24-oxocalciol+2reduced [adrenodoxin]+dioxygen+2hydronCHEBI:47813+2oxidized [adrenodoxin]+water
Catalysed by CYP24A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24976CC BY 4.0Reference data