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Proteins/UNIPROT:Q9BZF3
Regulates cellular transport and efflux of cholesterol. Plays a role in phosphatidylinositol-4-phosphate (PI4P) turnover at the neuronal membrane. Localizes at the neurons plasma membrane-endoplasmic reticulum contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) from the endoplasmic reticulum for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) from the plasma membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol..
Function from UniProtKB (Q9BZF3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
13 statements
13 statements · 6 reference databases · Subject: OSBPL6 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea
1 reaction
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+a 1,2-diacyl-sn-glycero-3-phospho-L-serinea 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+a 1,2-diacyl-sn-glycero-3-phospho-L-serine
Transported by OSBPL9 or OSBPL11 or OSBPL10 or OSBPL8 or OSBPL6 or OSBPL5
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:81667CC BY 4.0Reference data
3 names
Resolves to: OSBPL6