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Proteins/UNIPROT:Q12908
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation..
Function from UniProtKB (Q12908), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
71 statements
71 statements · 6 reference databases · Subject: SLC10A2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
36 reactions
glycocholate+sodium(1+)glycocholate+sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01862CC BY 4.0Reference data
10 names
Resolves to: SLC10A2
Human-GEM MAR01863CC BY 4.0Reference data
chenodeoxycholate+2sodium(1+)chenodeoxycholate+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01864CC BY 4.0Reference data
2sodium(1+)+taurocholate2sodium(1+)+taurocholate
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01865CC BY 4.0Reference data
2sodium(1+)+taurochenodeoxycholate2sodium(1+)+taurochenodeoxycholate
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01866CC BY 4.0Reference data
glycochenodeoxycholic acid+2sodium(1+)glycochenodeoxycholic acid+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01867CC BY 4.0Reference data
2sodium(1+)+taurolithocholate2sodium(1+)+taurolithocholate
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05435CC BY 4.0Reference data
glycolithocholic acid+2sodium(1+)glycolithocholic acid+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05436CC BY 4.0Reference data
2sodium(1+)+tauroursodeoxycholate2sodium(1+)+tauroursodeoxycholate
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05437CC BY 4.0Reference data
glycoursodeoxycholate+2sodium(1+)glycoursodeoxycholate+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05438CC BY 4.0Reference data
2sodium(1+)+MAM02950e2sodium(1+)+MAM02950c
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05439CC BY 4.0Reference data
estrone 3-sulfate+2sodium(1+)estrone 3-sulfate+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07946CC BY 4.0Reference data