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© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P53602

MVD

Protein·UNIPROT:P53602

Open in the graph

Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis..

Function from UniProtKB (P53602), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

disseminated superficial actinic porokeratosis has a germline basis in MVDDiseaseGenCC HGNC:7529|MONDO:0019212Inferred only
nonsyndromic genetic hearing loss has a germline basis in MVDDiseaseGenCC HGNC:7529|MONDO:0019497Inferred only
porokeratosis 7, multiple types has a germline basis in MVDDiseaseGenCC HGNC:7529|MONDO:0013868Inferred only

Statements

46 statements

46 statements · 5 reference databases · Subject: MVD · Sources: gene ontology, Hetionet, Reactome, Rhea, WikiPathways

Search this listOrder

ACSF3 covaries with MVDProteinHetionet hetionet:covaries:197322-4597Inferred only
MVD covaries with CFAP74ProteinHetionet hetionet:covaries:4597-85452Inferred only
NINL covaries with MVDProteinHetionet hetionet:covaries:22981-4597Inferred only
POU5F2 covaries with MVDProteinHetionet hetionet:covaries:134187-4597Inferred only
QTGAL covaries with MVDProteinHetionet hetionet:covaries:146712-4597Inferred only
STK25 covaries with MVDProteinHetionet hetionet:covaries:10494-4597Inferred only
MVD interacts with BTAF1ProteinHetionet hetionet:interacts:4597-9044Inferred only
EEF1G interacts with MVDProteinHetionet hetionet:interacts:1937-4597Inferred only
EIF4EBP1 interacts with MVDProteinHetionet hetionet:interacts:1978-4597Inferred only
MVD interacts with GNB5ProteinHetionet hetionet:interacts:10681-4597Inferred only
HSPA9 interacts with MVDProteinHetionet hetionet:interacts:3313-4597Inferred only
MVD interacts with UBCProteinHetionet hetionet:interacts:4597-7316Inferred only

Show the remaining 34

MVD participates in Activation of gene expression by SREBF (SREBP)PathwayReactome R-HSA-2426168Inferred only
MVD participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
MVD participates in Aspirin and miRNAsPathwayWikiPathways WP4707Inferred only
MVD participates in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinPathwayReactome R-HSA-446193Inferred only
MVD participates in Cholesterol biosynthesisPathwayReactome R-HSA-191273Inferred only
MVD participates in Cholesterol biosynthesis pathwayPathwayWikiPathways WP197Inferred only
MVD participates in Cholesterol biosynthesis pathway in hepatocytesPathwayWikiPathways WP5329Inferred only
MVD participates in Cholesterol metabolismPathwayWikiPathways WP5304Inferred only
MVD participates in Cholesterol metabolism with Bloch and Kandutsch Russell pathwaysPathwayWikiPathways WP4718Inferred only
MVD participates in Cholesterol synthesis disordersPathwayWikiPathways WP5193Inferred only
MVD participates in Enterocyte cholesterol metabolismPathwayWikiPathways WP5333Inferred only
MVD participates in Lanosterol biosynthesisPathwayReactome R-HSA-9969896Inferred only
MVD participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
MVD participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
MVD participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
MVD participates in Metabolism of steroidsPathwayReactome R-HSA-8957322Inferred only
MVD participates in Mevalonate arm of cholesterol biosynthesis pathwayPathwayWikiPathways WP4190Inferred only
MVD participates in Mevalonate arm of cholesterol biosynthesis pathway with inhibitorsPathwayWikiPathways WP4189Inferred only
MVD participates in Mevalonate pathwayPathwayWikiPathways WP3963Inferred only
MVD participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
MVD participates in Regulation of cholesterol biosynthesis by SREBP (SREBF)PathwayReactome R-HSA-1655829Inferred only
MVD participates in Sterol regulatory element binding proteins SREBP signalingPathwayWikiPathways WP1982Inferred only
MVD participates in Synthesis of dolichyl-phosphatePathwayReactome R-HSA-446199Inferred only
MVD participates in Synthesis of substrates in N-glycan biosythesisPathwayReactome R-HSA-446219Inferred only
MVD regulates positive regulation of cell population proliferationBiological processgene ontology P53602|GO:0008284Inferred only
ABAT increases the expression of MVDProteinHetionet hetionet:regulates:18-4597Inferred only
ATP6V0B increases the expression of MVDProteinHetionet hetionet:regulates:533-4597Inferred only
GM2A increases the expression of MVDProteinHetionet hetionet:regulates:2760-4597Inferred only
LRRC40 decreases the expression of MVDProteinHetionet hetionet:regulates:55631-4597Inferred only
NSDHL decreases the expression of MVDProteinHetionet hetionet:regulates:50814-4597Inferred only
PCK2 decreases the expression of MVDProteinHetionet hetionet:regulates:5106-4597Inferred only
RAP1A increases the expression of MVDProteinHetionet hetionet:regulates:5906-4597Inferred only
RPIA increases the expression of MVDProteinHetionet hetionet:regulates:22934-4597Inferred only
isopentenyl diphosphate is a substrate of MVDCompoundRhea RHEA:23732Inferred only

Reactions

3 reactions

MAM00164x+ATPADP+carbon dioxide+isopentenyl diphosphate+phosphate(3-)
Catalysed by MVD
Reaction pageLeft to rightBalancedEC 4.1.1.33peroxisome
Human-GEM MAR00441CC BY 4.0Reference data
MAM00164c+ATPADP+carbon dioxide+isopentenyl diphosphate+phosphate(3-)

Other names

4 names

Resolves to: MVD

Also called: MDDaseMevalonate (diphospho)decarboxylaseMevalonate pyrophosphate decarboxylaseMPD

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Catalysed by MVD

Reaction pageLeft to rightBalancedEC 4.1.1.33cytosol

Human-GEM MAR01451CC BY 4.0Reference data

CHEBI:57557+ATP(4-)isopentenyl diphosphate+ADP(3-)+carbon dioxide+hydrogenphosphate

Catalysed by MVD

Reaction pageDirection not assertedBalanced

Rhea RHEA:23732CC BY 4.0Reference data