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Proteins/UNIPROT:O60494
Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface..
Function from UniProtKB (O60494), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
33 statements
33 statements · 4 reference databases · Subject: CUBN · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
4 reactions
calcidiol+proton+NADPH(4-)+dioxygencalcitriol+water+NADP(3-)
Catalysed by CYP27B1 & CUBN & GC & LRP2
Reaction pageLeft to rightBalancedEC 1.14.15.18cytosol
Human-GEM MAR02118CC BY 4.0Reference data
MAM01600eMAM01600c
Transported by CUBN
5 names
Resolves to: CUBN
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06884CC BY 4.0Reference data
MAM00620m+proton+NADPH(4-)+dioxygenMAM00519m+water+NADP(3-)
Catalysed by CYP27B1 & CUBN & GC & LRP2
Reaction pageLeft to rightBalancedEC 1.14.15.18mitochondrial matrix
Human-GEM MAR08004CC BY 4.0Reference data
calcidiol+proton+NADPH(4-)+dioxygencalcitriol+water+NADP(3-)
Catalysed by CYP27B1 & CUBN & GC & LRP2
Reaction pageLeft to rightBalancedEC 1.14.15.18mitochondrial matrix
Human-GEM MAR08008CC BY 4.0Reference data