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Proteins/UNIPROT:Q86UW1
Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). In the complex, SLC51A/OST-alpha adopts a G protein-coupled receptor fold and constitutes a bile acid recognition site. Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols. Able to transport eicosanoids such as prostaglandin E2 (By similarity)..
Function from UniProtKB (Q86UW1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
45 statements
45 statements · 7 reference databases · Subject: SLC51A · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
28 reactions
ATP+glycocholate+waterADP+glycocholate+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC4 or SLC51A or SLC51B or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01868CC BY 4.0Reference data
3 names
Resolves to: SLC51A
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01870CC BY 4.0Reference data
ATP+water+taurochenodeoxycholateADP+proton+phosphate(3-)+taurochenodeoxycholate
Transported by ABCB11 or ABCC1 or ABCC3 or ABCC4 or SLC51A or SLC51B
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01872CC BY 4.0Reference data
ATP+glycochenodeoxycholic acid+waterADP+glycochenodeoxycholic acid+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC4 or SLC51A or SLC51B
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01874CC BY 4.0Reference data
MAM00517e+hydrogencarbonateMAM00517c+hydrogencarbonate
Transported by SLCO1B3 or SLCO1B1 or SLC51A or SLC51B
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR12143CC BY 4.0Reference data
hydrogencarbonate+MAM03206ehydrogencarbonate+MAM03206c
Transported by SLCO1B3 or SLCO1B1 or SLC51A or SLC51B
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR12148CC BY 4.0Reference data
hydrogencarbonate+MAM03207ehydrogencarbonate+MAM03207c
Transported by SLCO1B3 or SLCO1B1 or SLC51A or SLC51B
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR12151CC BY 4.0Reference data
hydrogencarbonate+MAM03208ehydrogencarbonate+MAM03208c
Transported by SLCO1B3 or SLCO1B1 or SLC51A or SLC51B
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR12155CC BY 4.0Reference data
hydrogencarbonate+MAM03209ehydrogencarbonate+MAM03209c
Transported by SLCO1B3 or SLCO1B1 or SLC51A or SLC51B
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR12159CC BY 4.0Reference data
hydrogencarbonate+MAM03310ehydrogencarbonate+MAM03310c
Transported by SLCO1B3 or SLCO1B1 or SLC51A or SLC51B
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR12162CC BY 4.0Reference data
hydrogencarbonate+MAM03311ehydrogencarbonate+MAM03311c
Transported by SLCO1B3 or SLCO1B1 or SLC51A or SLC51B
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR12165CC BY 4.0Reference data
hydrogencarbonate+hyocholatehydrogencarbonate+hyocholate
Transported by SLCO1B3 or SLCO1B1 or SLC51A or SLC51B
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR12263CC BY 4.0Reference data