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Proteins/UNIPROT:O76062
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis..
Function from UniProtKB (O76062), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
114 statements
114 statements · 5 reference databases · Subject: TM7SF2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol+proton+NADPH(4-)4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol+NADP(3-)
Catalysed by TM7SF2
Reaction pageLeft to rightBalancedEC 1.3.1.70endoplasmic reticulum
Human-GEM MAR00101CC BY 4.0Reference data
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol+proton+NADPH(4-)4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol+NADP(3-)
10 names
Resolves to: TM7SF2
Reaction pageLeft to rightBalancedEC 1.3.1.70cytosol
Human-GEM MAR01484CC BY 4.0Reference data
4,4-dimethyl-8,14-cholestadien-3beta-ol+proton+NADPH(4-)MAM00943c+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.3.1.70cytosol
Human-GEM MAR01540CC BY 4.0Reference data
proton+NADPH(4-)+4,4-dimethyl-8,14-cholestadien-3beta-olMAM00943c+NADP(3-)
Catalysed by TM7SF2
Reaction pageReversibleBalancedEC 1.3.1.70cytosol
Human-GEM MAR03420CC BY 4.0Reference data
proton+NADPH(4-)+4,4-dimethyl-8,14-cholestadien-3beta-olMAM00943r+NADP(3-)
Catalysed by TM7SF2
Reaction pageReversibleBalancedEC 1.3.1.70endoplasmic reticulum
Human-GEM MAR03434CC BY 4.0Reference data
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol+NADP(3-)4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:18561CC BY 4.0Reference data
CHEBI:86131+NADPH(4-)+hydronCHEBI:16608+NADP(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:46456CC BY 4.0Reference data
4,4-dimethyl-8,14-cholestadien-3beta-ol+NADPH(4-)+hydronCHEBI:87044+NADP(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:46812CC BY 4.0Reference data