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Proteins/UNIPROT:Q15800
Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol. Also involved in drug metabolism, as it can metabolize eldecalcitol (ED-71 or 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol), a second-generation vitamin D analog, into 1alpha,2beta,25-trihydroxy vitamin D3; this reaction occurs via enzymatic hydroxylation and spontaneous O-dehydroxypropylation..
Function from UniProtKB (Q15800), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
109 statements
109 statements · 6 reference databases · Subject: MSMO1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
21 reactions
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol+3proton+3NADPH(4-)+3dioxygenMAM00953r+4water+3NADP(3-)
Catalysed by MSMO1
Reaction pageLeft to rightBalancedEC 4.2.1.17endoplasmic reticulum
Human-GEM MAR00116CC BY 4.0Reference data
5 names
Resolves to: MSMO1
Reaction pageLeft to rightBalancedendoplasmic reticulum
Human-GEM MAR00118CC BY 4.0Reference data
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol+proton+NADPH(4-)+dioxygenMAM00961c+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01490CC BY 4.0Reference data
MAM00961c+proton+NADPH(4-)+dioxygenMAM00957c+2water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01493CC BY 4.0Reference data
MAM00957c+proton+NADPH(4-)+dioxygenMAM00953c+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01494CC BY 4.0Reference data
MAM00968c+proton+NADPH(4-)+dioxygenMAM00963c+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01502CC BY 4.0Reference data
MAM00963c+proton+NADPH(4-)+dioxygenMAM00959c+2water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01503CC BY 4.0Reference data
MAM00959c+proton+NADPH(4-)+dioxygenMAM00955c+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01504CC BY 4.0Reference data
MAM00943c+proton+NADPH(4-)+dioxygenMAM00962c+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01543CC BY 4.0Reference data
MAM00962c+proton+NADPH(4-)+dioxygenMAM00958c+2water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01544CC BY 4.0Reference data
MAM00958c+proton+NADPH(4-)+dioxygenMAM00954c+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01545CC BY 4.0Reference data
MAM00967c+proton+NADPH(4-)+dioxygenMAM00964c+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.18.9cytosol
Human-GEM MAR01548CC BY 4.0Reference data