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Proteins/UNIPROT:Q9H2F3
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity)..
Function from UniProtKB (Q9H2F3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
30 statements
30 statements · 5 reference databases · Subject: HSD3B7 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
12 reactions
5 names
Resolves to: HSD3B7
Human-GEM MAR01098CC BY 4.0Reference data
7alpha-hydroxycholesterol+NAD(+)7alpha-hydroxycholest-4-en-3-one+proton+NADH(2-)
Catalysed by HSD3B7
Reaction pageLeft to rightBalancedEC 1.1.1.181endoplasmic reticulum
Human-GEM MAR01584CC BY 4.0Reference data
7alpha-hydroxycholesterol+NADP(3-)7alpha-hydroxycholest-4-en-3-one+proton+NADPH(4-)
Catalysed by HSD3B7
Reaction pageLeft to rightBalancedEC 1.1.1.181endoplasmic reticulum
Human-GEM MAR01585CC BY 4.0Reference data
(24S)-7alpha-dihydroxycholesterol+NAD(+)MAM00978c+proton+NADH(2-)
Catalysed by HSD3B7
Reaction pageLeft to rightBalancedEC 1.1.1.181cytosol
Human-GEM MAR01738CC BY 4.0Reference data
MAM01448c+NAD(+)MAM00979c+proton+NADH(2-)
Catalysed by HSD3B7
Reaction pageLeft to rightBalancedEC 1.1.1.181cytosol
Human-GEM MAR01766CC BY 4.0Reference data
7alpha,25-dihydroxy-4-cholesten-3-one+proton+NADH(2-)7alpha,25-dihydroxycholesterol+NAD(+)
Catalysed by HSD3B7
Reaction pageReversibleBalancedEC 1.1.1.181endoplasmic reticulum
Human-GEM MAR01778CC BY 4.0Reference data
MAM00747r+proton+NADPH(4-)MAM01087r+NADP(3-)
Catalysed by HSD17B14 or HSD3B7 or DHRS2 or HTATIP2 or RDH10 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 and 12 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-endoplasmic reticulum
Human-GEM MAR01813CC BY 4.0Reference data
25-hydroxycholesterol+NADP(3-)7alpha-hydroxycholest-4-en-3-one+proton+NADPH(4-)
Catalysed by HSD3B7
Reaction pageReversibleBalancedEC 1.1.1.181endoplasmic reticulum
Human-GEM MAR02184CC BY 4.0Reference data
7alpha-hydroxycholesterol+NAD(1-)7alpha-hydroxycholest-4-en-3-one+NADH(2-)+hydron
Catalysed by HSD3B7
Reaction pageLeft to rightBalanced
Rhea RHEA:11896CC BY 4.0Reference data
7alpha,25-dihydroxycholesterol+NAD(1-)7alpha,25-dihydroxy-4-cholesten-3-one+NADH(2-)+hydron
Catalysed by HSD3B7
Reaction pageLeft to rightBalanced
Rhea RHEA:47156CC BY 4.0Reference data
CHEBI:76592+NAD(1-)CHEBI:87476+NADH(2-)+hydron
Catalysed by HSD3B7
Reaction pageLeft to rightBalanced
Rhea RHEA:47180CC BY 4.0Reference data
(24S)-7alpha-dihydroxycholesterol+NAD(1-)CHEBI:63838+NADH(2-)+hydron
Catalysed by HSD3B7
Reaction pageLeft to rightBalanced
Rhea RHEA:47200CC BY 4.0Reference data