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Proteins/UNIPROT:Q14534
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis..
Function from UniProtKB (Q14534), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
46 statements
46 statements · 7 reference databases · Subject: SQLE · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
proton+NADPH(4-)+dioxygen+squalenewater+NADP(3-)+(S)-2,3-epoxysqualene
Catalysed by SQLE
Reaction pageLeft to rightBalancedEC 1.14.14.17cytosol
Human-GEM MAR01470CC BY 4.0Reference data
3 names
Resolves to: SQLE
Catalysed by SQLE
Reaction pageLeft to rightBalancedEC 1.14.14.17endoplasmic reticulum
Human-GEM MAR01714CC BY 4.0Reference data
squalene+reduced [NADPH--hemoprotein reductase]+dioxygen(S)-2,3-epoxysqualene+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by SQLE
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:25282CC BY 4.0Reference data