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Proteins/UNIPROT:P51857
Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one)..
Function from UniProtKB (P51857), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
32 statements
32 statements · 6 reference databases · Subject: AKR1D1 · Sources: Bgee, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
22 reactions
MAM01178c+proton+NADPH(4-)MAM01177c+NADP(3-)
Catalysed by AKR1D1
Reaction pageLeft to rightBalancedEC 1.3.1.3, 1.3.99.6cytosol
Human-GEM MAR01595CC BY 4.0Reference data
7alpha-hydroxycholest-4-en-3-one+proton+NADPH(4-)MAM01181c+NADP(3-)
Catalysed by AKR1D1
Reaction pageLeft to rightBalanced
4 names
Resolves to: AKR1D1
Human-GEM MAR01673CC BY 4.0Reference data
MAM00976c+proton+NADPH(4-)MAM01081c+NADP(3-)
Catalysed by AKR1D1
Reaction pageLeft to rightBalancedEC 1.3.1.3cytosol
Human-GEM MAR01740CC BY 4.0Reference data
MAM00978c+proton+NADPH(4-)MAM01083c+NADP(3-)
Catalysed by AKR1D1
Reaction pageLeft to rightBalancedEC 1.3.1.3cytosol
Human-GEM MAR01741CC BY 4.0Reference data
MAM00977c+proton+NADPH(4-)MAM01082c+NADP(3-)
Catalysed by AKR1D1
Reaction pageLeft to rightBalancedEC 1.3.1.3cytosol
Human-GEM MAR01768CC BY 4.0Reference data
MAM00979c+proton+NADPH(4-)MAM01084c+NADP(3-)
Catalysed by AKR1D1
Reaction pageLeft to rightBalancedEC 1.3.1.3cytosol
Human-GEM MAR01769CC BY 4.0Reference data
androst-4-ene-3,17-dione+proton+NADPH(4-)5alpha-androstan-3,17-dione+NADP(3-)
Catalysed by AKR1D1
Reaction pageReversibleBalancedEC 1.3.1.3, 1.3.99.6cytosol
Human-GEM MAR02014CC BY 4.0Reference data
CHEBI:16074+NADP(3-)CHEBI:16175+NADPH(4-)+hydron
Catalysed by AKR1D1
Reaction pageRight to leftBalanced
Rhea RHEA:11524CC BY 4.0Reference data
CHEBI:18093+NADP(3-)cortisone+NADPH(4-)+hydron
Catalysed by AKR1D1
Reaction pageRight to leftBalanced
Rhea RHEA:14037CC BY 4.0Reference data
CHEBI:28477+NADPH(4-)+hydronCHEBI:2288+NADP(3-)
Catalysed by AKR1D1
Reaction pageLeft to rightBalanced
Rhea RHEA:46632CC BY 4.0Reference data
5beta-dihydrotestosterone+NADP(3-)testosterone+NADPH(4-)+hydron
Catalysed by AKR1D1
Reaction pageDirection not assertedBalanced
Rhea RHEA:46636CC BY 4.0Reference data
7alpha-hydroxycholest-4-en-3-one+NADPH(4-)+hydronCHEBI:2290+NADP(3-)
Catalysed by AKR1D1
Reaction pageLeft to rightBalanced
Rhea RHEA:46640CC BY 4.0Reference data