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Proteins/UNIPROT:Q53GQ0
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation..
Function from UniProtKB (Q53GQ0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
170 statements
170 statements · 6 reference databases · Subject: HSD17B12 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
43 reactions
MAM00307c+proton+NADH(2-)MAM00321c+NAD(+)
Catalysed by PTGR1 or HSD17B12 or TECRL
Reaction pageReversibleBalancedEC 1.3.1.-cytosol
Human-GEM MAR01074CC BY 4.0Reference data
12-oxo-leukotriene B4+proton+NADH(2-)MAM00253c+NAD(+)
Catalysed by PTGR1
7 names
Resolves to: HSD17B12
Reaction pageLeft to rightBalancedEC 1.3.1.-cytosol
Human-GEM MAR01228CC BY 4.0Reference data
12-oxo-leukotriene B4+proton+NADH(2-)MAM00253m+NAD(+)
Catalysed by PTGR1 or HSD17B12 or TECRL
Reaction pageLeft to rightBalancedEC 1.3.1.-mitochondrial matrix
Human-GEM MAR01229CC BY 4.0Reference data
12-oxo-leukotriene B4+proton+NADH(2-)MAM00253x+NAD(+)
Catalysed by PTGR1 or HSD17B12 or TECRL
Reaction pageLeft to rightBalancedEC 1.3.1.-peroxisome
Human-GEM MAR01230CC BY 4.0Reference data
androst-4-ene-3,17-dione+proton+NADPH(4-)NADP(3-)+testosterone
Catalysed by HSD17B6 or HSD17B1 or HSD17B3 or HSD17B7 or HSD17B12 or AKR1C3 or HSD17B11
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR01974CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62cytosol
Human-GEM MAR02036CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62endoplasmic reticulum
Human-GEM MAR02041CC BY 4.0Reference data
3-oxooctadecanoyl-CoA+proton+NADPH(4-)MAM00793c+NADP(3-)
Catalysed by HSD17B12
Reaction pageLeft to rightBalancedEC 1.1.1.330cytosol
Human-GEM MAR02191CC BY 4.0Reference data
3-oxoeicosanoyl-CoA+proton+NADPH(4-)MAM00777c+NADP(3-)
Catalysed by HSD17B12
Reaction pageLeft to rightBalancedEC 1.1.1.330cytosol
Human-GEM MAR02202CC BY 4.0Reference data
3-oxodocosanoyl-CoA+proton+NADPH(4-)MAM00776c+NADP(3-)
Catalysed by HSD17B12
Reaction pageLeft to rightBalancedEC 1.1.1.330cytosol
Human-GEM MAR02208CC BY 4.0Reference data
3-oxotetracosanoyl-CoA+proton+NADPH(4-)MAM00800c+NADP(3-)
Catalysed by HSD17B12
Reaction pageLeft to rightBalancedEC 1.1.1.330cytosol
Human-GEM MAR02212CC BY 4.0Reference data
3-oxohexacosanoyl-CoA+proton+NADPH(4-)MAM00783c+NADP(3-)
Catalysed by HSD17B12
Reaction pageLeft to rightBalancedEC 1.1.1.330cytosol
Human-GEM MAR02217CC BY 4.0Reference data