Loading the page.
Proteins/UNIPROT:Q14739
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane..
Function from UniProtKB (Q14739), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
699 statements
699 statements · 5 reference databases · Subject: LBR · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
5 reactions
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol+proton+NADPH(4-)4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.3.1.70cytosol
Human-GEM MAR01484CC BY 4.0Reference data
4,4-dimethyl-8,14-cholestadien-3beta-ol+proton+NADPH(4-)MAM00943c+NADP(3-)
9 names
Resolves to: LBR
Reaction pageLeft to rightBalancedEC 1.3.1.70cytosol
Human-GEM MAR01540CC BY 4.0Reference data
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol+NADP(3-)4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:18561CC BY 4.0Reference data
CHEBI:86131+NADPH(4-)+hydronCHEBI:16608+NADP(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:46456CC BY 4.0Reference data
4,4-dimethyl-8,14-cholestadien-3beta-ol+NADPH(4-)+hydronCHEBI:87044+NADP(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:46812CC BY 4.0Reference data