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Proteins/UNIPROT:O00767
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)..
Function from UniProtKB (O00767), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
153 statements
153 statements · 8 reference databases · Subject: SCD · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
20 reactions
proton+NADH(2-)+dioxygen+palmitoyl-CoA2water+NAD(+)+(9Z)-hexadecenoyl-CoA
Catalysed by SCD
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR00144CC BY 4.0Reference data
8 names
Resolves to: SCD
Catalysed by SCD
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR00146CC BY 4.0Reference data
proton+NADH(2-)+dioxygen+octadecanoyl-CoA2water+NAD(+)+(11Z)-octadecenoyl-CoA
Catalysed by SCD
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR00147CC BY 4.0Reference data
proton+NADH(2-)+dioxygen+octadecanoyl-CoA(2E)-octadecenoyl-CoA+2water+NAD(+)
Catalysed by SCD
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR00148CC BY 4.0Reference data
2MAM01825c+2proton+dioxygen+palmitoyl-CoA2MAM01823c+2water+(9Z)-hexadecenoyl-CoA
Reaction pageLeft to rightBalance undeterminableEC 1.14.19.1cytosol
Human-GEM MAR02126CC BY 4.0Reference data
2MAM01825c+2proton+dioxygen+octadecanoyl-CoA2MAM01823c+2water+oleoyl-CoA
Reaction pageLeft to rightBalance undeterminableEC 1.14.19.1cytosol
Human-GEM MAR02128CC BY 4.0Reference data
proton+tetradecanoyl-CoA+NADPH(4-)+dioxygenMAM00129c+2water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR02281CC BY 4.0Reference data
proton+tetradecanoyl-CoA+NADPH(4-)+dioxygen(7Z)-tetradecenoyl-CoA+2water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR02282CC BY 4.0Reference data
proton+tetradecanoyl-CoA+NADPH(4-)+dioxygen(5Z)-tetradecenoyl-CoA+2water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR02284CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+palmitoyl-CoA2water+NADP(3-)+(9Z)-hexadecenoyl-CoA
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR02286CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+palmitoyl-CoA(7Z)-hexadecenoyl-CoA+2water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR02287CC BY 4.0Reference data
proton+heptadecanoyl-CoA+NADPH(4-)+dioxygenMAM00004c+2water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.19.1cytosol
Human-GEM MAR02288CC BY 4.0Reference data