ABCC3

ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarized cells such as hepatocytes and intestinal epithelial cells, where it mediates the efflux of conjugated substrates from intestine and liver into the bloodstream. Involved in enterohepatic recirculation of steroid glucuronates. Shares substrate specificity with MRP2, displaying higher affinity for both estrogen and androgen glucuronates such as 17beta-estradiol, estrone, testosterone and 5alpha-dihydrotestosterone glucuronates. Involved in sinusoidal efflux of mono- and bis-glucuronidated bilirubin from hepatocytes into the blood for renal uptake and excretion. May selectively transport steroid sulfate conjugates. Has transporter activity toward androgen sulfates such as androsterone and dehydroepiandrosterone sulfates but is inactive toward estrone 3-sulfate. Can transport various bile acid conjugates such as taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate and taurolithocholate-3-sulfate. Does not contribute substantially to bile acids physiology, but provides an alternative route for the export of bile acids and glucuronate conjugates from cholestatic hepatocytes to avoid liver damage (By similarity). Can also transport glutathione conjugates such as leukotriene C4 (LTC4). Transports various xenobiotics. Confers resistance to anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells. May contribute to the transport of organic compounds in testes across the blood-testis-barrier (Probable)..

Function from UniProtKB (O15438), read 2026-09-23. CC BY 4.0.